Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0004403
UniProt IDQ6UUV9
Primary gene name(s)CRTC1
Synonym gene name(s)KIAA0616, MECT1, TORC1, WAMTP1
Protein nameCREB-regulated transcription coactivator 1
Protein functionTranscriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element, CRE sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1, HTLV-1 long terminal repeats, LTR. In the hippocampus, involved in late-phase long-term potentiation, L-LTP maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons, By similarity. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:15589160}. Nucleus {ECO:0000269|PubMed:15589160}. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins, PubMed:16817901. Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels, PubMed:15589160. Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus, SCN of the brain, By similarity. {ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q6UUV9
Gene Ontology
(Biological Process)
Complete annatation
energy homeostasis [GO:0097009];
entrainment of circadian clock by photoperiod [GO:0043153];
membrane hyperpolarization [GO:0060081];
memory [GO:0007613];
positive regulation of CREB transcription factor activity [GO:0032793];
positive regulation of dendrite development [GO:1900006];
positive regulation of long-term synaptic potentiation [GO:1900273];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
protein homotetramerization [GO:0051289];
rhythmic process [GO:0048511];
transcription, DNA-templated [GO:0006351];
viral process [GO:0016032]
Gene Ontology
(Molecular Function)
Complete annatation
cAMP response element binding protein binding [GO:0008140]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
dendrite [GO:0030425];
neuronal cell body [GO:0043025];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
plasma membrane [GO:0005886];
synapse [GO:0045202]
Protein-protein interaction116952
Phylogenetic treeQ6UUV9
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.26307571546450.0004391902453451110.00177465827824169
AZA vs. DISU0.3899674858576220.1290001274196470.694977812982046
AZA vs. IL7-0.1681807459953650.5107750941662380.999311006273513
AZA vs. SAHA-1.603940668198670.006574331804642620.0739563265844648
DISU vs. CD31.640149441069971.63896337459501e-050.000115070954395181
DISU vs. IL7-0.5671404543429980.02955729109211150.222231143664205
DISU vs. SAHA-1.991236780082270.0005714379148135110.0137354717929098
DMSO vs. AZA0.06050002235090840.7246515347273171
DMSO vs. CD31.311157322702447.97458219589098e-050.000367279366496783
DMSO vs. DISU-0.3313765442219740.1794037775681380.691330415689155
DMSO vs. IL7-0.2204501790353050.3051593217871350.788338514346039
DMSO vs. SAHA-1.668827896522810.003269161846769180.0409794434521426
HIV vs. Mock in Activation0.5002797146691450.436480818463190.999983755607037
HIV vs. Mock in Latency0.1201352345855310.4763506630708370.999834320637052
IL7 vs. CD31.099440237302990.003437350238339350.0122225006233756
SAHA vs. CD3-0.363257546333360.5857295654264090.685055844080403
SAHA vs. IL7-1.437585048269880.01706915620987570.0905668640294496
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.813274 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.971 0.924 0.866 0.948 1.087
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05166 HTLV-I infection - Homo sapiens (human)
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