Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0004195
UniProt IDP42773
Primary gene name(s)CDKN2C
Synonym gene name(s)CDKN6
Protein nameCyclin-dependent kinase 4 inhibitor C
Protein functionInteracts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P42773
Gene Ontology
(Biological Process)
Complete annatation
cell cycle arrest [GO:0007050];
G1/S transition of mitotic cell cycle [GO:0000082];
negative regulation of cell growth [GO:0030308];
negative regulation of cell proliferation [GO:0008285];
negative regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0045736];
negative regulation of phosphorylation [GO:0042326];
oligodendrocyte differentiation [GO:0048709];
regulation of cyclin-dependent protein serine/threonine kinase activity [GO:0000079]
Gene Ontology
(Molecular Function)
Complete annatation
cyclin-dependent protein serine/threonine kinase inhibitor activity [GO:0004861];
protein kinase binding [GO:0019901]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
nucleus [GO:0005634]
Protein-protein interaction107465
Phylogenetic treeP42773
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4017030292902080.6454187917880370.741896890621515
AZA vs. DISU0.08058650737898680.7575742020333780.976021571236163
AZA vs. IL7-0.1321672640894610.6285593731575690.999311006273513
AZA vs. SAHA0.3552724441027410.1594410050421590.509629709500743
DISU vs. CD30.4710369021953450.5875366003527260.700896384434709
DISU vs. IL7-0.2230131201981060.5171057273453870.835624786176853
DISU vs. SAHA0.2770965284637260.3556582264863220.732958448157441
DMSO vs. AZA-0.112722105186560.5331747404820511
DMSO vs. CD30.2840959289092140.7520754964217210.820777843639034
DMSO vs. DISU-0.1932611644190740.4934260090154350.906268123810189
DMSO vs. IL7-0.01360128770154870.9656052733121480.993414945980946
DMSO vs. SAHA0.4607406646115950.05887909118304680.277588323124468
HIV vs. Mock in Activation0.297351573035210.8591717480065980.999983755607037
HIV vs. Mock in Latency0.6167859923100780.06810193069118580.999834320637052
IL7 vs. CD30.2749095374347370.7525658858362090.835335307719461
SAHA vs. CD30.7336414607774510.4263579326715030.540706391093121
SAHA vs. IL70.4853359823320140.1242595760264090.327177091532242
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.022965 0.919188
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.062 0.982 1.136 1.39 1.286
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1BU9 NMR - A=1-168.
1G3N X-ray 2.9Å B/F=1-168.
1IHB X-ray 1.9Å A/B=1-162.
1MX2 X-ray 2.2Å A/B=1-168.
1MX4 X-ray 2.0Å A/B=1-168.
1MX6 X-ray 2.0Å A/B=1-168.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa01522 Endocrine resistance - Homo sapiens (human)
hsa04110 Cell cycle - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)