Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0004152
UniProt IDP28907
Primary gene name(s)CD38
Synonym gene name(s)unknown
Protein nameADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1
Protein functionSynthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
Subcellular locationMembrane;
Single-pass type II membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P28907
Gene Ontology
(Biological Process)
Complete annatation
apoptotic signaling pathway [GO:0097190];
B cell receptor signaling pathway [GO:0050853];
female pregnancy [GO:0007565];
long term synaptic depression [GO:0060292];
negative regulation of apoptotic process [GO:0043066];
negative regulation of bone resorption [GO:0045779];
negative regulation of transcription, DNA-templated [GO:0045892];
positive regulation of B cell proliferation [GO:0030890];
positive regulation of cell growth [GO:0030307];
positive regulation of cytosolic calcium ion concentration [GO:0007204];
positive regulation of insulin secretion [GO:0032024];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of vasoconstriction [GO:0045907];
response to drug [GO:0042493];
response to estradiol [GO:0032355];
response to hydroperoxide [GO:0033194];
response to hypoxia [GO:0001666];
response to interleukin-1 [GO:0070555];
response to progesterone [GO:0032570];
response to retinoic acid [GO:0032526];
signal transduction [GO:0007165]
Gene Ontology
(Molecular Function)
Complete annatation
NAD(P+ nucleosidase activity [GO:0050135];
NAD+ nucleosidase activity [GO:0003953];
phosphorus-oxygen lyase activity [GO:0016849];
transferase activity [GO:0016740]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
integral component of membrane [GO:0016021];
membrane [GO:0016020];
nucleus [GO:0005634];
plasma membrane [GO:0005886]
Protein-protein interaction107390
Phylogenetic treeP28907
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: 2.311020408; Folds changes 16h: 2.167155988; Tested: untested;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.822703013024071.08069649340514e-071.03220897012689e-06
AZA vs. DISU-0.9577271095165060.000273172225428220.0324236072921652
AZA vs. IL7-0.1968440178176270.5398895644006430.999311006273513
AZA vs. SAHA0.4304452553044440.08391018978221070.361492483788809
DISU vs. CD3-2.790749852321157.56283924374657e-132.78054240878624e-11
DISU vs. IL70.7508071217409510.02989258203865640.223305586834859
DISU vs. SAHA1.388617740865484.31674258027925e-060.0003269227508914
DMSO vs. AZA-0.03833972696649580.827309721999521
DMSO vs. CD3-1.873688047368642.13419865113806e-082.12643536239384e-07
DMSO vs. DISU0.9168538037779440.0002938391711524440.0299199750626171
DMSO vs. IL7-0.1516172880304920.6261260395803440.9187953190929
DMSO vs. SAHA0.4618368863032340.05480727509930360.266709862131613
HIV vs. Mock in Activation-0.1988375156849760.7638660928577870.999983755607037
HIV vs. Mock in Latency-0.3838329056368710.4215176581747140.999834320637052
IL7 vs. CD3-2.011410979914676.80363375571424e-065.48695407168972e-05
SAHA vs. CD3-1.416666562282030.0001008561544927340.00048590225326263
SAHA vs. IL70.6251963273187860.04321243470633940.166399858069748
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
1.11 0.0328

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock 0.807 8.53E-07 2.32E-05