Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003931
UniProt IDQ9NR09
Primary gene name(s)BIRC6
Synonym gene name(s)KIAA1289
Protein nameBaculoviral IAP repeat-containing protein 6
Protein functionAnti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating, E2 with ubiquitin ligase, E3 activity, forming a chimeric E2/E3 ubiquitin ligase. Its tragets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. {ECO:0000269|PubMed:14765125, ECO:0000269|PubMed:15200957, ECO:0000269|PubMed:18329369}.
Subcellular locationGolgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:18329369}. Midbody {ECO:0000269|PubMed:18329369}. Endosome {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18329369}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18329369}. Note=Concentrates in a pericentriolar compartment in interphase, moves partially to spindle poles in metaphase, and finally localizes to the spindle midzone and the midbody in telophase and during cytokinesis.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NR09
Gene Ontology
(Biological Process)
Complete annatation
apoptotic process [GO:0006915];
cell division [GO:0051301];
labyrinthine layer development [GO:0060711];
mitotic nuclear division [GO:0007067];
negative regulation of apoptotic process [GO:0043066];
negative regulation of extrinsic apoptotic signaling pathway [GO:2001237];
positive regulation of cell proliferation [GO:0008284];
protein phosphorylation [GO:0006468];
protein ubiquitination [GO:0016567];
regulation of cell proliferation [GO:0042127];
regulation of cytokinesis [GO:0032465];
spongiotrophoblast layer development [GO:0060712]
Gene Ontology
(Molecular Function)
Complete annatation
cysteine-type endopeptidase inhibitor activity [GO:0004869];
ligase activity [GO:0016874];
ubiquitin conjugating enzyme activity [GO:0061631];
ubiquitin-protein transferase activity [GO:0004842]
Gene Ontology
(Cellular Component)
Complete annatation
endosome [GO:0005768];
membrane [GO:0016020];
microtubule organizing center [GO:0005815];
midbody [GO:0030496];
spindle pole [GO:0000922];
trans-Golgi network [GO:0005802]
Protein-protein interaction121521
Phylogenetic treeQ9NR09
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.4152761021015680.2062744182631660.312490504780625
AZA vs. DISU0.2600046347051290.3035574118182080.864202986671203
AZA vs. IL70.0472516188408160.8051863199993280.999311006273513
AZA vs. SAHA0.04011180661375990.8690513339272890.969729795515578
DISU vs. CD30.6619827634641420.07094575124471350.142514213706289
DISU vs. IL7-0.221718781559720.3785021737497690.749693899524079
DISU vs. SAHA-0.2181068007847520.4540983042031090.795163102087061
DMSO vs. AZA0.07421964045586850.6563161360865941
DMSO vs. CD30.4788790054151560.1359801913422440.219376909677758
DMSO vs. DISU-0.1872993308555310.4420396008527440.884783740848831
DMSO vs. IL7-0.01985729112465060.9117431895348240.981734048116649
DMSO vs. SAHA-0.04089849667026110.861919832497550.964308662433988
HIV vs. Mock in Activation0.3821113161900680.5452916950309590.999983755607037
HIV vs. Mock in Latency0.2425398278838840.1402426827957240.999834320637052
IL7 vs. CD30.4695355407591750.1452576112117250.252621203853043
SAHA vs. CD30.4309428813201670.2236462416808270.329650710302236
SAHA vs. IL7-0.01063694260579770.965065628360660.987074429780859
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.314197 0.0168952
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.049 1.014 1.066 1.092 1.08
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3CEG X-ray 2.0Å A/B=4498-4820.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)
hsa04215 Apoptosis - multiple species - Homo sapiens (human)