Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003905
UniProt IDP51572
Primary gene name(s)BCAP31
Synonym gene name(s)BAP31, DXS1357E
Protein nameB-cell receptor-associated protein 31
Protein functionFunctions as a chaperone protein. Is one of the most abundant endoplasmic reticulum, ER proteins. Plays a role in the export of secreted proteins in the ER, the recognition of abnormally folded protein and their targeting to the ER associated-degradation, ERAD. Also serves as a cargo receptor for the export of transmembrane proteins. May be involved in CASP8-mediated apoptosis. {ECO:0000269|PubMed:10958671, ECO:0000269|PubMed:18287538, ECO:0000269|PubMed:9396746}.
Subcellular locationEndoplasmic reticulum membrane {ECO:0000269|PubMed:9334338, ECO:0000269|PubMed:9396746};
Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:11042173, ECO:0000269|PubMed:9396746};
Multi-pass membrane protein {ECO:0000255}. Note=May shuttle between the ER and the intermediate compartment/cis-Golgi complex. {ECO:0000269|PubMed:9396746}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P51572
Gene Ontology
(Biological Process)
Complete annatation
antigen processing and presentation of peptide antigen via MHC class I [GO:0002474];
calcium-mediated signaling using intracellular calcium source [GO:0035584];
cellular component disassembly involved in execution phase of apoptosis [GO:0006921];
ER to Golgi vesicle-mediated transport [GO:0006888];
intracellular protein transport [GO:0006886];
negative regulation of endoplasmic reticulum calcium ion concentration [GO:0032471];
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043280];
positive regulation of cytosolic calcium ion concentration [GO:0007204];
positive regulation of ER-associated ubiquitin-dependent protein catabolic process [GO:1903071];
positive regulation of intrinsic apoptotic signaling pathway [GO:2001244];
positive regulation of mitochondrial calcium ion concentration [GO:0051561];
positive regulation of retrograde protein transport, ER to cytosol [GO:1904154];
protein localization to endoplasmic reticulum exit site [GO:0070973];
spermatogenesis [GO:0007283]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
clathrin-coated vesicle [GO:0030136];
cytosol [GO:0005829];
endoplasmic reticulum [GO:0005783];
endoplasmic reticulum-Golgi intermediate compartment membrane [GO:0033116];
endoplasmic reticulum membrane [GO:0005789];
Golgi cisterna membrane [GO:0032580];
integral component of lumenal side of endoplasmic reticulum membrane [GO:0071556];
integral component of plasma membrane [GO:0005887];
lipid particle [GO:0005811];
membrane [GO:0016020];
mitochondrion [GO:0005739];
perinuclear endoplasmic reticulum [GO:0097038]
Protein-protein interaction115437
Phylogenetic treeP51572
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.222341172283430.4970125213179040.61401032993449
AZA vs. DISU-0.04443937109482530.8605680687293190.991021233304583
AZA vs. IL70.03505134284482150.8553607909953150.999311006273513
AZA vs. SAHA-0.09192832071377350.7064426453808220.91681931791089
DISU vs. CD30.1657286632203760.6476296996710790.74932209471336
DISU vs. IL70.06980407013491930.7817520096026520.949783328881365
DISU vs. SAHA-0.04492829029435290.8773742893597130.968569287645784
DMSO vs. AZA0.01569749736843790.925408878049221
DMSO vs. CD30.2273621571069260.4768762666313320.587131493690832
DMSO vs. DISU0.05839907051038850.810988125339410.97885454093317
DMSO vs. IL70.0266297649610110.882290395047360.974736638191125
DMSO vs. SAHA-0.1132748065511580.631297338416920.880012812449812
HIV vs. Mock in Activation0.1164849323855440.8520309481167040.999983755607037
HIV vs. Mock in Latency0.005573623054581770.973106450464840.999834320637052
IL7 vs. CD30.2632840738098010.4123427082731860.549632264043309
SAHA vs. CD30.107398852613130.7612722359598750.829048460465047
SAHA vs. IL7-0.1292210124017740.5959416319041510.794312007193973
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0562494 0.756011
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.028 0.968 1.016 1.072 0.941
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4JZL X-ray 2.2Å A/B/C/D=168-233.
4JZP X-ray 2.1Å A/B=168-233.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef interacts with 23284715
Envelope transmembrane glycoprotein gp41 interacts with 22190034

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)