Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003870
UniProt IDQ16864
Primary gene name(s)ATP6V1F
Synonym gene name(s)ATP6S14, VATF
Protein nameV-type proton ATPase subunit F
Protein functionSubunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q16864
Gene Ontology
(Biological Process)
Complete annatation
ATP hydrolysis coupled proton transport [GO:0015991];
insulin receptor signaling pathway [GO:0008286];
ion transmembrane transport [GO:0034220];
phagosome acidification [GO:0090383];
proton transport [GO:0015992];
transferrin transport [GO:0033572]
Gene Ontology
(Molecular Function)
Complete annatation
ATPase activity, uncoupled [GO:0042624];
ATPase coupled ion transmembrane transporter activity [GO:0042625];
hydrogen ion transmembrane transporter activity [GO:0015078];
proton-transporting ATPase activity, rotational mechanism [GO:0046961]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
membrane [GO:0016020];
proton-transporting two-sector ATPase complex [GO:0016469];
proton-transporting V-type ATPase, V1 domain [GO:0033180];
vacuolar proton-transporting V-type ATPase complex [GO:0016471]
Protein-protein interaction114710
Phylogenetic treeQ16864
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.02941904374480080.9289047067618450.954154838844149
AZA vs. DISU-0.19568704385010.4408242275753440.91814655876178
AZA vs. IL70.1034349916831120.5923842684635620.999311006273513
AZA vs. SAHA-0.1472570210717240.5473697960139340.846044559239116
DISU vs. CD3-0.2367779902773840.514690514979730.638312586002653
DISU vs. IL70.2892855971127760.2521483823950230.638417343736139
DISU vs. SAHA0.05074672442307040.8621894867812230.962987302666301
DMSO vs. AZA-0.0358295007182720.8318255830617571
DMSO vs. CD3-0.07459024843373090.816616141029120.870960861210881
DMSO vs. DISU0.1584071684284010.517504043951580.914196078390533
DMSO vs. IL70.1463102741906640.4181718761652610.852614705558083
DMSO vs. SAHA-0.1176728944807440.6188019170496520.875136319220589
HIV vs. Mock in Activation0.09899970704066650.8737136809301290.999983755607037
HIV vs. Mock in Latency0.1001328931853920.5484771949011590.999834320637052
IL7 vs. CD30.07996785175292360.8041180550429230.872164599817369
SAHA vs. CD3-0.1998865377633240.5750555946642080.676403981547738
SAHA vs. IL7-0.2527388814703380.3012845373870030.550025810411975
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0973499 0.550888
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.943 1.034 1.052 1.068 1.033
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00190 Oxidative phosphorylation - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04145 Phagosome - Homo sapiens (human)
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
hsa04966 Collecting duct acid secretion - Homo sapiens (human)
hsa05110 Vibrio cholerae infection - Homo sapiens (human)
hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
hsa05323 Rheumatoid arthritis - Homo sapiens (human)
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