Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003867
UniProt IDP21283
Primary gene name(s)ATP6V1C1
Synonym gene name(s)ATP6C, ATP6D, VATC
Protein nameV-type proton ATPase subunit C 1
Protein functionSubunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P21283
Gene Ontology
(Biological Process)
Complete annatation
ATP hydrolysis coupled proton transport [GO:0015991];
insulin receptor signaling pathway [GO:0008286];
ion transmembrane transport [GO:0034220];
phagosome acidification [GO:0090383];
proton transport [GO:0015992];
regulation of macroautophagy [GO:0016241];
transferrin transport [GO:0033572]
Gene Ontology
(Molecular Function)
Complete annatation
hydrogen-exporting ATPase activity, phosphorylative mechanism [GO:0008553];
proton-transporting ATPase activity, rotational mechanism [GO:0046961];
transporter activity [GO:0005215]
Gene Ontology
(Cellular Component)
Complete annatation
apical part of cell [GO:0045177];
cytoplasmic vesicle [GO:0031410];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
lysosomal membrane [GO:0005765];
plasma membrane [GO:0005886];
proton-transporting two-sector ATPase complex [GO:0016469];
proton-transporting V-type ATPase, V1 domain [GO:0033180]
Protein-protein interaction107011
Phylogenetic treeP21283
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.794296565611180.01640568759932910.0395623683484083
AZA vs. DISU0.3401924523879350.181070366330570.766714246228705
AZA vs. IL70.1336349399089610.4897801215993470.999311006273513
AZA vs. SAHA-0.02409527533378790.9216312185924140.982071981797342
DISU vs. CD3-0.4677116736852530.1976928787637280.316015106520089
DISU vs. IL7-0.2149973793896940.3947482740508870.760235953363443
DISU vs. SAHA-0.3632776906136430.2156790527555830.590861995214642
DMSO vs. AZA-0.05833110724562410.7301033551648181
DMSO vs. CD3-0.8639104695668830.007593338166014370.0196586422875076
DMSO vs. DISU-0.4002540160116150.1030290291715520.574958447471729
DMSO vs. IL70.1991471495405280.2714761026045120.769218388958909
DMSO vs. SAHA0.02697176026500240.9092631144520650.97863874102711
HIV vs. Mock in Activation-0.03641453202239610.9533627749163420.999983755607037
HIV vs. Mock in Latency0.001552121019389090.9925558362073860.999834320637052
IL7 vs. CD3-0.6518173671631060.04369445644789570.0981663935535568
SAHA vs. CD3-0.8436615045985060.01856781677782650.043288520860434
SAHA vs. IL7-0.1619180013709350.5082334999207340.734104233212452
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.0195994 0.924608
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.002 0.934 1.006 1.061 0.907
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01694 D-tartaric acid experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00190 Oxidative phosphorylation - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04145 Phagosome - Homo sapiens (human)
hsa04150 mTOR signaling pathway - Homo sapiens (human)
hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
hsa04966 Collecting duct acid secretion - Homo sapiens (human)
hsa05110 Vibrio cholerae infection - Homo sapiens (human)
hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
hsa05323 Rheumatoid arthritis - Homo sapiens (human)
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