Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003863
UniProt IDQ9Y487
Primary gene name(s)ATP6V0A2
Synonym gene name(s)unknown
Protein nameV-type proton ATPase 116 kDa subunit a isoform 2
Protein functionPart of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. {ECO:0000269|PubMed:16415858, ECO:0000269|PubMed:18157129}.
Subcellular locationCell membrane;
Multi-pass membrane protein. Endosome membrane. Note=In kidney proximal tubules, also detected in subapical vesicles. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y487
Gene Ontology
(Biological Process)
Complete annatation
ATP hydrolysis coupled proton transport [GO:0015991];
ATP synthesis coupled proton transport [GO:0015986];
immune response [GO:0006955];
insulin receptor signaling pathway [GO:0008286];
ion transmembrane transport [GO:0034220];
phagosome acidification [GO:0090383];
regulation of macroautophagy [GO:0016241];
transferrin transport [GO:0033572];
vacuolar acidification [GO:0007035];
vacuolar proton-transporting V-type ATPase complex assembly [GO:0070072]
Gene Ontology
(Molecular Function)
Complete annatation
ATPase binding [GO:0051117];
proton-transporting ATPase activity, rotational mechanism [GO:0046961]
Gene Ontology
(Cellular Component)
Complete annatation
acrosomal vesicle [GO:0001669];
cytoplasm [GO:0005737];
endosome membrane [GO:0010008];
focal adhesion [GO:0005925];
integral component of membrane [GO:0016021];
lysosomal membrane [GO:0005765];
phagocytic vesicle membrane [GO:0030670];
plasma membrane [GO:0005886];
vacuolar proton-transporting V-type ATPase, V0 domain [GO:0000220];
vacuolar proton-transporting V-type ATPase complex [GO:0016471]
Protein-protein interaction117089
Phylogenetic treeQ9Y487
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.071995624697170.001227252591991630.00434817843594215
AZA vs. DISU0.0185569873607160.9417801317349310.996198528027442
AZA vs. IL70.07867947571225130.6833502092109670.999311006273513
AZA vs. SAHA0.07307294716790830.7657779451310750.937568490498197
DISU vs. CD3-1.065860494474460.004006287995480530.0134951475405304
DISU vs. IL70.05151465091066110.8390401129769090.966158445371157
DISU vs. SAHA0.05539235484444240.8514792054727460.960203429486898
DMSO vs. AZA0.00649245836237210.9692271572538041
DMSO vs. CD3-1.078163252252780.0008693748279634540.00302823856260565
DMSO vs. DISU-0.01415019643818030.9539770133209960.993828264951078
DMSO vs. IL70.07963466617247990.6589026131462110.929465642394234
DMSO vs. SAHA0.05981652891132320.8006797458767680.944065313977753
HIV vs. Mock in Activation-0.1307042756564460.8339535371245540.999983755607037
HIV vs. Mock in Latency-0.04398566457992780.7905867967730050.999834320637052
IL7 vs. CD3-0.9849129840934270.002395609741392970.00898457965464449
SAHA vs. CD3-1.024271236516210.004071662879109870.0119726750415972
SAHA vs. IL7-0.009805071311975030.9679880488995890.987992969915217
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0769039 0.66055
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.915 0.922 0.809 0.781 1.072
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00190 Oxidative phosphorylation - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04142 Lysosome - Homo sapiens (human)
hsa04145 Phagosome - Homo sapiens (human)
hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
hsa04966 Collecting duct acid secretion - Homo sapiens (human)
hsa05110 Vibrio cholerae infection - Homo sapiens (human)
hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
hsa05152 Tuberculosis - Homo sapiens (human)
hsa05323 Rheumatoid arthritis - Homo sapiens (human)
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