Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003851
UniProt IDP30049
Primary gene name(s)ATP5D
Synonym gene name(s)unknown
Protein nameATP synthase subunit delta, mitochondrial
Protein functionMitochondrial membrane ATP synthase, F(1F(0 ATP synthase or Complex V produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1 - containing the extramembraneous catalytic core, and F(0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1 domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3beta(3 subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.
Subcellular locationMitochondrion. Mitochondrion inner membrane.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P30049
Gene Ontology
(Biological Process)
Complete annatation
ATP biosynthetic process [GO:0006754];
ATP synthesis coupled proton transport [GO:0015986];
mitochondrial ATP synthesis coupled proton transport [GO:0042776];
oxidative phosphorylation [GO:0006119];
response to copper ion [GO:0046688]
Gene Ontology
(Molecular Function)
Complete annatation
proton-transporting ATPase activity, rotational mechanism [GO:0046961];
proton-transporting ATP synthase activity, rotational mechanism [GO:0046933];
transmembrane transporter activity [GO:0022857];
transporter activity [GO:0005215]
Gene Ontology
(Cellular Component)
Complete annatation
mitochondrial inner membrane [GO:0005743];
mitochondrial matrix [GO:0005759];
mitochondrial proton-transporting ATP synthase complex [GO:0005753];
mitochondrial proton-transporting ATP synthase complex, catalytic core F(1 [GO:0000275];
mitochondrion [GO:0005739]
Protein-protein interaction106998
Phylogenetic treeP30049
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.02923712578145750.9290854840019060.954154838844149
AZA vs. DISU-0.4958563766946580.218876987063340.808166062514192
AZA vs. IL7-0.08850877605290360.7648442053843480.999311006273513
AZA vs. SAHA0.01242512287897790.9634728255679920.990968034535802
DISU vs. CD3-0.4762796853610540.2662767695845650.394443398655438
DISU vs. IL70.3968089431112870.3434118958938830.724350682887965
DISU vs. SAHA0.510913812837810.2054891977242650.578826732409034
DMSO vs. AZA-0.3336430654320680.1922793868226941
DMSO vs. CD3-0.3111175276028980.3331134999483340.447069476768076
DMSO vs. DISU0.1615998599315690.6833344279483710.957247128816386
DMSO vs. IL70.2520678500589070.3783553876966370.832872524258073
DMSO vs. SAHA0.3405239934509440.1914475092692370.527203301388754
HIV vs. Mock in Activation0.4601448534623080.4696935750006730.999983755607037
HIV vs. Mock in Latency-0.1506982723204780.3737673161325180.999834320637052
IL7 vs. CD3-0.05562042459123090.8639290502881530.913120395993079
SAHA vs. CD30.01968416768302860.9556542332996280.970400195123334
SAHA vs. IL70.09941781372665440.7424097472920450.882680902295741
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.147871 0.345665
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.009 0.936 0.952 1.006 0.943
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00228 Enflurane approved, vet_approved unknown other/unknown
DB00753 Isoflurane approved, vet_approved unknown unknown
DB01028 Methoxyflurane approved, vet_approved unknown unknown
DB01159 Halothane approved, vet_approved unknown other/unknown
DB01189 Desflurane approved unknown other/unknown
DB01236 Sevoflurane approved, vet_approved unknown other/unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu interacts with 22190034
Vpr downregulates 23874603

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00190 Oxidative phosphorylation - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa05010 Alzheimer's disease - Homo sapiens (human)
hsa05012 Parkinson's disease - Homo sapiens (human)
hsa05016 Huntington's disease - Homo sapiens (human)