Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003793
UniProt IDQ92747
Primary gene name(s)ARPC1A
Synonym gene name(s)SOP2L
Protein nameActin-related protein 2/3 complex subunit 1A
Protein functionProbably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor, NPF mediates the formation of branched actin networks.
Subcellular locationCytoplasm, cytoskeleton {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92747
Gene Ontology
(Biological Process)
Complete annatation
actin cytoskeleton organization [GO:0030036];
Arp2/3 complex-mediated actin nucleation [GO:0034314];
ephrin receptor signaling pathway [GO:0048013];
Fc-gamma receptor signaling pathway involved in phagocytosis [GO:0038096]
Gene Ontology
(Molecular Function)
Complete annatation
actin binding [GO:0003779];
actin filament binding [GO:0051015]
Gene Ontology
(Cellular Component)
Complete annatation
actin cytoskeleton [GO:0015629];
Arp2/3 protein complex [GO:0005885];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
muscle cell projection membrane [GO:0036195]
Protein-protein interaction115803
Phylogenetic treeQ92747
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.1993290378633670.5450909634161170.657487067701705
AZA vs. DISU-0.1320553897149480.6030577033218360.955158276076142
AZA vs. IL70.04597665470124850.8118199176856730.999311006273513
AZA vs. SAHA-0.2537677898092250.2999186992196080.67186424015996
DISU vs. CD3-0.3435047831445970.3500312691112910.483760094488274
DISU vs. IL70.1685050966873510.5057117213212810.830044367655729
DISU vs. SAHA-0.1197631366031390.6819948229068130.904720681056087
DMSO vs. AZA-0.03223258375656590.8484340680529111
DMSO vs. CD3-0.2445723463893430.446380049192930.558484797034424
DMSO vs. DISU0.09744530848580020.69106173513350.957954410639349
DMSO vs. IL70.08576302727879440.6349406505590340.920865342972506
DMSO vs. SAHA-0.2269260986895280.3374474089419010.690469938621548
HIV vs. Mock in Activation0.01611300811228150.9793370266633520.999983755607037
HIV vs. Mock in Latency-0.00394125640913690.9810564907004140.999834320637052
IL7 vs. CD3-0.1466586215689670.6491225648516280.75775625380153
SAHA vs. CD3-0.4767728682914270.1807474891053860.279399390790662
SAHA vs. IL7-0.3022256327521760.2162770451935940.454435476073282
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.166374 0.337064
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.965 1.096 1.228 1.224 1.158
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)
hsa04666 Fc gamma R-mediated phagocytosis - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa05100 Bacterial invasion of epithelial cells - Homo sapiens (human)
hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
hsa05131 Shigellosis - Homo sapiens (human)
hsa05132 Salmonella infection - Homo sapiens (human)
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