Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003724
UniProt IDO95996
Primary gene name(s)APC2
Synonym gene name(s)APCL
Protein nameAdenomatous polyposis coli protein 2
Protein functionStabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases, PubMed:25753423. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1, PubMed:10021369, PubMed:11691822, PubMed:9823329. {ECO:0000269|PubMed:10021369, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423, ECO:0000269|PubMed:9823329}.
Subcellular locationCytoplasm, cytoskeleton {ECO:0000269|PubMed:10644998, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423}. Golgi apparatus {ECO:0000269|PubMed:11691822}. Cytoplasm {ECO:0000269|PubMed:11691822}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10646860}. Note=Associated with actin filaments, PubMed:11691822, PubMed:25753423. Associated with microtubule network, PubMed:10644998, PubMed:11691822, PubMed:25753423. {ECO:0000269|PubMed:10644998, ECO:0000269|PubMed:11691822, ECO:0000269|PubMed:25753423}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O95996
Gene Ontology
(Biological Process)
Complete annatation
cell fate specification [GO:0001708];
cell migration [GO:0016477];
cell proliferation [GO:0008283];
negative regulation of canonical Wnt signaling pathway [GO:0090090];
negative regulation of catenin import into nucleus [GO:0035414];
negative regulation of microtubule depolymerization [GO:0007026];
pattern specification process [GO:0007389];
positive regulation of protein catabolic process [GO:0045732];
regulation of cell differentiation [GO:0045595];
Wnt signaling pathway [GO:0016055]
Gene Ontology
(Molecular Function)
Complete annatation
beta-catenin binding [GO:0008013];
gamma-catenin binding [GO:0045295]
Gene Ontology
(Cellular Component)
Complete annatation
actin filament [GO:0005884];
beta-catenin destruction complex [GO:0030877];
catenin complex [GO:0016342];
cytoplasm [GO:0005737];
Golgi apparatus [GO:0005794];
lamellipodium membrane [GO:0031258];
microtubule [GO:0005874];
microtubule cytoskeleton [GO:0015630];
perinuclear region of cytoplasm [GO:0048471]
Protein-protein interaction115585
Phylogenetic treeO95996
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.213735314464420.0005232174665051880.00207150151234409
AZA vs. DISU0.517720856883670.05153197159351110.508237708036081
AZA vs. IL7-0.1534934487097430.472800840675820.999311006273513
AZA vs. SAHA0.3216272769429390.2163752147023320.585357780838232
DISU vs. CD31.71860160515787.88104255489142e-066.04266711456934e-05
DISU vs. IL7-0.6818918610462880.01005857199258730.117910554267693
DISU vs. SAHA-0.1934439628132880.5207552420800850.836599594524907
DMSO vs. AZA0.1017921031766360.5942988852687321
DMSO vs. CD31.299676923440390.0001574012406827530.000672122928255576
DMSO vs. DISU-0.4204009023132220.1010170802814490.572469160742217
DMSO vs. IL7-0.2450292867271970.2213869922614940.729446701738132
DMSO vs. SAHA0.2161841796586110.3911602050886990.736989054993346
HIV vs. Mock in Activation0.2439522456960460.7099320788261350.999983755607037
HIV vs. Mock in Latency-0.06076757493724450.7379864116079060.999834320637052
IL7 vs. CD31.063929008409250.001920567030523570.00746678020404481
SAHA vs. CD31.513028084355185.23352087059559e-050.000270841893955616
SAHA vs. IL70.4734459853304170.06809687454361320.225404542571459
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.300398 0.0313509
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.916 1.009 1.019 0.929 0.875
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04310 Wnt signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)
hsa05210 Colorectal cancer - Homo sapiens (human)
hsa05213 Endometrial cancer - Homo sapiens (human)
hsa05217 Basal cell carcinoma - Homo sapiens (human)
hsa05224 Breast cancer - Homo sapiens (human)