Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003646
UniProt IDP49419
Primary gene name(s)ALDH7A1
Synonym gene name(s)ATQ1
Protein nameAlpha-aminoadipic semialdehyde dehydrogenase
Protein functionMultifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism. {ECO:0000269|PubMed:16491085, ECO:0000269|PubMed:20207735}.
Subcellular locationCytoplasm, cytosol {ECO:0000269|PubMed:20207735}. Nucleus {ECO:0000269|PubMed:20207735}.;
SUBCELLULAR LOCATION: Isoform 1: Mitochondrion {ECO:0000269|PubMed:20207735}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P49419
Gene Ontology
(Biological Process)
Complete annatation
cellular aldehyde metabolic process [GO:0006081];
choline catabolic process [GO:0042426];
glycine betaine biosynthetic process from choline [GO:0019285];
lysine catabolic process [GO:0006554];
sensory perception of sound [GO:0007605]
Gene Ontology
(Molecular Function)
Complete annatation
aldehyde dehydrogenase, NAD activity [GO:0004029];
betaine-aldehyde dehydrogenase activity [GO:0008802];
L-aminoadipate-semialdehyde dehydrogenase activity [GO:0004043]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
mitochondrial matrix [GO:0005759];
mitochondrion [GO:0005739];
nucleus [GO:0005634]
Protein-protein interaction106990
Phylogenetic treeP49419
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.061681006072260.2184032615618270.326435338978566
AZA vs. DISU-0.5923899809364340.5517421842060820.946928765276725
AZA vs. IL7-0.4785201454477340.6094904530401110.999311006273513
AZA vs. SAHA0.09423249138842060.9224854183034850.982099385232483
DISU vs. CD30.4619090033501520.563996729564720.681388691308695
DISU vs. IL70.1036092619871420.9080571420160630.982189124739072
DISU vs. SAHA0.6829370621706120.4669209379478490.802390587891908
DMSO vs. AZA0.002979164888062840.9975938888929661
DMSO vs. CD31.041053865363810.1902375747754280.287339990374155
DMSO vs. DISU0.5901770460719410.5370563084395640.92112338311561
DMSO vs. IL7-0.472474572102830.5968391541902820.911970258876874
DMSO vs. SAHA0.08522685662971480.9267532266518280.982780458369212
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.01441019403111850.9751895362091440.999834320637052
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD31.124188547914220.1392342831423250.226986223166902
SAHA vs. IL70.5661071566742070.5147652213735340.739262468506321
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
NOTEST 0.610364 1
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.993 1.166 1.252 1.109 1.239
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00157 NADH nutraceutical unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2J6L X-ray 1.3Å A/B/C/D/E/F/G/H=30-527.
4X0T X-ray 2.4Å A/B/C/D=29-539.
4X0U X-ray 1.9Å A/B/C/D=29-539.
4ZUK X-ray 2.0Å A/B/C/D/E/F/G/H=29-539.
4ZUL X-ray 1.7Å A/B/C/D/E/F/G/H=29-539.
4ZVW X-ray 2.4Å A/B/C/D/E/F/G/H=29-539.
4ZVX X-ray 1.9Å A/B=29-539.
4ZVY X-ray 1.9Å A/B=29-539.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
hsa00053 Ascorbate and aldarate metabolism - Homo sapiens (human)
hsa00071 Fatty acid degradation - Homo sapiens (human)
hsa00260 Glycine# serine and threonine metabolism - Homo sapiens (human)
hsa00280 Valine# leucine and isoleucine degradation - Homo sapiens (human)
hsa00300 Lysine biosynthesis - Homo sapiens (human)
hsa00310 Lysine degradation - Homo sapiens (human)
hsa00330 Arginine and proline metabolism - Homo sapiens (human)
hsa00340 Histidine metabolism - Homo sapiens (human)
hsa00380 Tryptophan metabolism - Homo sapiens (human)
hsa00410 beta-Alanine metabolism - Homo sapiens (human)
hsa00561 Glycerolipid metabolism - Homo sapiens (human)
hsa00620 Pyruvate metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa01230 Biosynthesis of amino acids - Homo sapiens (human)