Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003562
UniProt IDP24666
Primary gene name(s)ACP1
Synonym gene name(s)unknown
Protein nameLow molecular weight phosphotyrosine protein phosphatase
Protein functionActs on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Isoform 3 does not possess phosphatase activity.
Subcellular locationCytoplasm.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P24666
Gene Ontology
(Biological Process)
Complete annatation
unknown
Gene Ontology
(Molecular Function)
Complete annatation
acid phosphatase activity [GO:0003993];
non-membrane spanning protein tyrosine phosphatase activity [GO:0004726]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytoplasmic side of plasma membrane [GO:0009898];
extracellular exosome [GO:0070062]
Protein-protein interaction106568
Phylogenetic treeP24666
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.264661349467660.000142738470667370.000660938319477295
AZA vs. DISU-0.1302537212656490.6066339130180520.955305607396123
AZA vs. IL70.1808708263918340.3473290876911280.999311006273513
AZA vs. SAHA-0.1108290712789560.6497765058963610.892539734816999
DISU vs. CD3-1.407768934129120.0001379619605532680.000749149349200273
DISU vs. IL70.3022342777685730.2306130139460040.614616495243197
DISU vs. SAHA0.02069722900293660.9433602233694790.987112540887413
DMSO vs. AZA0.01958350860487090.9070856927952241
DMSO vs. CD3-1.25828271486110.0001073110328804190.000479430815641613
DMSO vs. DISU0.1475989041735870.5452680906376250.922272808496102
DMSO vs. IL70.1686599165451620.3488807999070440.81588697150311
DMSO vs. SAHA-0.1365475030609530.5625737137762840.845487479090783
HIV vs. Mock in Activation-0.2246683566768150.7179738735418080.999983755607037
HIV vs. Mock in Latency-0.0136080864944620.9343361476425840.999834320637052
IL7 vs. CD3-1.075596530025470.0009176567197700660.0039373298426115
SAHA vs. CD3-1.400193357164540.0001021098374527350.000491313936913384
SAHA vs. IL7-0.2951039862120850.2263547588082430.466703820855623
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1.9 0.000286215 1.5 0.000818364 1.5 0.004251217
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.00281001 0.989006
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.041 0.972 1.112 1.156 0.999
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
-0.76 0.0293 -0.43 0.5104 -0.07 0.5416 Cell growth and proliferation at 4 hpi
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00173 Adenine approved, nutraceutical unknown unknown
DB04214 4-Nitrophenyl Phosphate experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1XWW X-ray 1.6Å A=2-158.
3N8I X-ray 1.5Å A=2-158.
4Z99 X-ray 2.3Å A=1-158.
4Z9A X-ray 2.1Å A=1-158.
4Z9B X-ray 2.4Å A=1-158.
5KQG X-ray 1.5Å A=1-158.
5KQL X-ray 1.4Å A=1-158.
5KQM X-ray 1.9Å A=1-158.
5KQP X-ray 2.0Å A=1-158.
5PNT X-ray 2.2Å A=2-158.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00730 Thiamine metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04520 Adherens junction - Homo sapiens (human)
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