Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003547
UniProt IDP45954
Primary gene name(s)ACADSB
Synonym gene name(s)unknown
Protein nameShort/branched chain specific acyl-CoA dehydrogenase, mitochondrial
Protein functionHas greatest activity toward short branched chain acyl-CoA derivative such as, s-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent.
Subcellular locationMitochondrion matrix.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P45954
Gene Ontology
(Biological Process)
Complete annatation
branched-chain amino acid catabolic process [GO:0009083];
fatty acid beta-oxidation using acyl-CoA dehydrogenase [GO:0033539];
fatty acid metabolic process [GO:0006631];
lipid homeostasis [GO:0055088]
Gene Ontology
(Molecular Function)
Complete annatation
acyl-CoA dehydrogenase activity [GO:0003995];
electron carrier activity [GO:0009055];
fatty-acyl-CoA binding [GO:0000062];
flavin adenine dinucleotide binding [GO:0050660];
oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [GO:0052890]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
mitochondrial matrix [GO:0005759];
mitochondrion [GO:0005739]
Protein-protein interaction106554
Phylogenetic treeP45954
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      Yes - Two siRNA pools inhibit HIV replication and inhibition of Tat-mediated transactivation of the HIV LTR is not observed
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      Negatively associated
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.074555765237120.00855184235992890.0228858963154915
AZA vs. DISU-0.5079752179359580.04555679508887020.484973961277987
AZA vs. IL7-0.007267415498639690.9699447559830150.999311006273513
AZA vs. SAHA0.09432630257607970.6995170138953340.9150836618274
DISU vs. CD30.554923015913510.1703777181396010.281732527779327
DISU vs. IL70.4917437322709220.05184940828912470.301090073173557
DISU vs. SAHA0.6028860180330980.03955485425974460.244308011492758
DMSO vs. AZA-0.02754051705806640.8700225916453431
DMSO vs. CD31.035848132648990.01085244741715220.0267187645594701
DMSO vs. DISU0.4788549561707580.05060811343666150.445067187377236
DMSO vs. IL70.02740896820943180.8792404541458540.97351733065793
DMSO vs. SAHA0.1149537422781170.6265571396550710.8781147043588
HIV vs. Mock in Activation0.03192685918824940.9723617997679150.999983755607037
HIV vs. Mock in Latency0.06463148960857740.6963085897690130.999834320637052
IL7 vs. CD31.075539441589220.008518878678513640.0261155208282172
SAHA vs. CD31.144306358336350.006549480443817980.0179651747885579
SAHA vs. IL70.09772410852141680.6889474559977630.853779347862843
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) unknown
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.359297 0.00605069
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.031 1.019 1.242 1.344 1.141
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00167 L-Isoleucine approved, nutraceutical unknown unknown
DB00313 Valproic Acid approved, investigational unknown inhibitor

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2JIF X-ray 2.0Å A/B/C/D=52-432.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00071 Fatty acid degradation - Homo sapiens (human)
hsa00280 Valine# leucine and isoleucine degradation - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa01212 Fatty acid metabolism - Homo sapiens (human)
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