Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003292
UniProt IDQ9Y2W2
Primary gene name(s)WBP11
Synonym gene name(s)NPWBP, SIPP1, SNP70
Protein nameWW domain-binding protein 11
Protein functionActivates pre-mRNA splicing. May inhibit PP1 phosphatase activity. {ECO:0000269|PubMed:10593949, ECO:0000269|PubMed:11375989, ECO:0000269|PubMed:14640981}.
Subcellular locationNucleus. Cytoplasm. Note=Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y2W2
Gene Ontology
(Biological Process)
Complete annatation
mRNA cis splicing, via spliceosome [GO:0045292];
positive regulation of protein targeting to mitochondrion [GO:1903955];
regulation of mitophagy [GO:1903146];
rRNA processing [GO:0006364]
Gene Ontology
(Molecular Function)
Complete annatation
poly(A RNA binding [GO:0044822];
protein phosphatase type 1 regulator activity [GO:0008599];
single-stranded DNA binding [GO:0003697];
WW domain binding [GO:0050699]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
intracellular membrane-bounded organelle [GO:0043231];
nuclear speck [GO:0016607];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
spliceosomal complex [GO:0005681]
Protein-protein interaction119702
Phylogenetic treeQ9Y2W2
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.8265009937977070.01225037332502410.031000273128738
AZA vs. DISU0.1753640696583580.4888392740996860.932025138886161
AZA vs. IL70.1118097398376830.5610899924526730.999311006273513
AZA vs. SAHA0.005375974561614170.9824207458967130.996243190432113
DISU vs. CD3-0.6633665295549920.06794083960931120.137999289613484
DISU vs. IL7-0.0728341737375340.7723329716689430.946655788918556
DISU vs. SAHA-0.1681650053399760.5657041540365280.859246937719707
DMSO vs. AZA-0.02237718659262210.8937921631434241
DMSO vs. CD3-0.8601574830529290.007546775437573870.0195582611331585
DMSO vs. DISU-0.1995633515866560.4135980543628270.872958358438067
DMSO vs. IL70.1414987483195680.4313242546762510.858351476593235
DMSO vs. SAHA0.02171918143870780.9266946366185880.982780458369212
HIV vs. Mock in Activation0.129924612940120.8344428275555370.999983755607037
HIV vs. Mock in Latency0.08981701335485060.5869193725588890.999834320637052
IL7 vs. CD3-0.7078949560135450.02812170503089630.0689362074306087
SAHA vs. CD3-0.8450373473526410.01804084171868670.0422166901709019
SAHA vs. IL7-0.1092772546470980.6545533795172380.83179376520341
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.486186 0.0981438
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.043 1.015 0.911 0.851 0.923
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
217821_s_at 1.59 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03040 Spliceosome - Homo sapiens (human)