Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003273
UniProt IDQ9Y277
Primary gene name(s)VDAC3
Synonym gene name(s)unknown
Protein nameVoltage-dependent anion-selective channel protein 3
Protein functionForms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. {ECO:0000250}.
Subcellular locationMitochondrion outer membrane.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y277
Gene Ontology
(Biological Process)
Complete annatation
adenine transport [GO:0015853];
regulation of cilium assembly [GO:1902017]
Gene Ontology
(Molecular Function)
Complete annatation
nucleotide binding [GO:0000166];
porin activity [GO:0015288];
voltage-gated anion channel activity [GO:0008308]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
mitochondrial outer membrane [GO:0005741];
mitochondrion [GO:0005739];
nucleus [GO:0005634];
pore complex [GO:0046930]
Protein-protein interaction113262
Phylogenetic treeQ9Y277
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.3805972259257030.38241063631160.50408370740672
AZA vs. DISU0.1800604316664550.4782830386895310.930532445702423
AZA vs. IL70.2187274509569180.2551536942770550.999311006273513
AZA vs. SAHA-0.0235511285921330.9231623418907930.982328461178844
DISU vs. CD3-0.2141735193813980.6606123722584310.759172897722313
DISU vs. IL70.02966410378520810.9066777471159280.982189124739072
DISU vs. SAHA-0.2019670020650280.4882239995082860.817558210732152
DMSO vs. AZA-0.008165110373320870.9611240980437821
DMSO vs. CD3-0.4014240657863220.3621358294536750.47642793386775
DMSO vs. DISU-0.1904487810581230.4361672837068370.882284188803474
DMSO vs. IL70.2341810959418710.1928570033410220.701742535690539
DMSO vs. SAHA-0.0217587234483260.9264716444302170.982780458369212
HIV vs. Mock in Activation-0.2082469482908120.8308272536910.999983755607037
HIV vs. Mock in Latency-0.0131754285762310.9364285850322240.999834320637052
IL7 vs. CD3-0.1537236588692720.7275235354786810.816405766101113
SAHA vs. CD3-0.4289613382247340.354539196392970.471031093153669
SAHA vs. IL7-0.245502408194030.3144665018886810.563378660502731
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0839345 0.615102
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.034 1.028 1.205 1.25 1.027
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
208845_at 1.32 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB01375 Aluminium monostearate approved unknown inhibitor
DB06098 PRLX 93936 investigational unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr interacts with 17254575
Envelope transmembrane glycoprotein gp41 interacts with 22190034

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04020 Calcium signaling pathway - Homo sapiens (human)
hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
hsa05012 Parkinson's disease - Homo sapiens (human)
hsa05016 Huntington's disease - Homo sapiens (human)
hsa05161 Hepatitis B - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)