Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003239
UniProt IDQ9UDW1
Primary gene name(s)UQCR10
Synonym gene name(s)UCRC
Protein nameCytochrome b-c1 complex subunit 9
Protein functionThis is a component of the ubiquinol-cytochrome c reductase complex, complex III or cytochrome b-c1 complex, which is part of the mitochondrial respiratory chain. This subunit interacts with cytochrome c1, By similarity. {ECO:0000250}.
Subcellular locationMitochondrion inner membrane {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9UDW1
Gene Ontology
(Biological Process)
Complete annatation
aerobic respiration [GO:0009060];
mitochondrial electron transport, ubiquinol to cytochrome c [GO:0006122];
mitochondrial respiratory chain complex III assembly [GO:0034551]
Gene Ontology
(Molecular Function)
Complete annatation
ubiquinol-cytochrome-c reductase activity [GO:0008121]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
mitochondrial inner membrane [GO:0005743];
mitochondrial respiratory chain complex III [GO:0005750]
Protein-protein interaction118920
Phylogenetic treeQ9UDW1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.1671546860428870.6131760177370860.715585670873664
AZA vs. DISU-0.1849253842268960.4668735782180790.925885056973993
AZA vs. IL7-0.003170239211532080.9869538426974570.999311006273513
AZA vs. SAHA-0.4147350994538210.09163177652109570.380826412814722
DISU vs. CD3-0.363555464512390.3193616205984730.452169150303337
DISU vs. IL70.1720117856086980.496503811713780.824117650015759
DISU vs. SAHA-0.2277073443156970.4363735663157140.782647389973121
DMSO vs. AZA-0.1983804564156240.2425166626126131
DMSO vs. CD3-0.3757001977898660.2453394852815380.350500660840775
DMSO vs. DISU-0.0148962482780910.9515575293329730.993447978824122
DMSO vs. IL70.2021675749539890.265678646628350.766513361016163
DMSO vs. SAHA-0.2220916567458080.3495541572597450.699990792461017
HIV vs. Mock in Activation-0.1642987144694210.7920671638907910.999983755607037
HIV vs. Mock in Latency-0.07779734814554260.6413818184101330.999834320637052
IL7 vs. CD3-0.1640263191651160.6120931386372980.72680635565464
SAHA vs. CD3-0.6051342187814020.09025790757867520.160494002030753
SAHA vs. IL7-0.4131403724576690.09208876160057570.273850067541345
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0554054 0.906584
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.048 1.095 1.058 1.064 0.996
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB07401 METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE experimental unknown unknown
DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol experimental unknown unknown
DB07636 5-HEPTYL-6-HYDROXY-1,3-BENZOTHIAZOLE-4,7-DIONE experimental unknown unknown
DB07763 (5S)-3-ANILINO-5-(2,4-DIFLUOROPHENYL)-5-METHYL-1,3-OXAZOLIDINE-2,4-DIONE experimental unknown unknown
DB07778 FAMOXADONE experimental unknown unknown
DB08330 METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE experimental unknown unknown
DB08453 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE experimental unknown unknown
DB04799 5-n-undecyl-6-hydroxy-4,7-dioxobenzothiazole experimental unknown unknown
DB08690 UBIQUINONE-2 experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00190 Oxidative phosphorylation - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa04260 Cardiac muscle contraction - Homo sapiens (human)
hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
hsa05010 Alzheimer's disease - Homo sapiens (human)
hsa05012 Parkinson's disease - Homo sapiens (human)
hsa05016 Huntington's disease - Homo sapiens (human)
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