Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0003197
UniProt IDP29597
Primary gene name(s)TYK2
Synonym gene name(s)unknown
Protein nameNon-receptor tyrosine-protein kinase TYK2
Protein functionProbably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. {ECO:0000269|PubMed:7526154}.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P29597
Gene Ontology
(Biological Process)
Complete annatation
cell differentiation [GO:0030154];
cell migration [GO:0016477];
innate immune response [GO:0045087];
intracellular signal transduction [GO:0035556];
peptidyl-tyrosine autophosphorylation [GO:0038083];
protein phosphorylation [GO:0006468];
regulation of cell proliferation [GO:0042127];
regulation of type I interferon-mediated signaling pathway [GO:0060338];
transmembrane receptor protein tyrosine kinase signaling pathway [GO:0007169];
type I interferon signaling pathway [GO:0060337]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
growth hormone receptor binding [GO:0005131];
non-membrane spanning protein tyrosine kinase activity [GO:0004715];
protein tyrosine kinase activity [GO:0004713]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytoskeleton [GO:0005856];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
extrinsic component of cytoplasmic side of plasma membrane [GO:0031234];
nucleus [GO:0005634]
Protein-protein interaction113148
Phylogenetic treeP29597
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.2885798145443380.3786694501901650.500158264242062
AZA vs. DISU0.117178911432320.6425840061688590.960057478314726
AZA vs. IL7-0.1618705678020640.3989713976473310.999311006273513
AZA vs. SAHA-0.4347750259009690.07477107201684490.339589978783344
DISU vs. CD30.3927185371164080.2793368795147450.408689131496192
DISU vs. IL7-0.2886238132975450.2514510359567950.637747925886918
DISU vs. SAHA-0.5489138435339040.0599270876223270.308878638015079
DMSO vs. AZA0.1051585815810390.5290875180174081
DMSO vs. CD30.3805539942900830.2346110853529620.338707810334679
DMSO vs. DISU-0.01415045771183590.9536589137739690.993828264951078
DMSO vs. IL7-0.2594968466954280.1483164233965540.649987368961978
DMSO vs. SAHA-0.5443344988816750.02109955943318240.146620778969154
HIV vs. Mock in Activation0.3040771967773550.6252480544259320.999983755607037
HIV vs. Mock in Latency0.07507352940119330.6483044114458770.999834320637052
IL7 vs. CD30.131704445091680.6816636397127590.783074159087754
SAHA vs. CD3-0.1689178399588790.6327763840816560.724725650411199
SAHA vs. IL7-0.2752174688664710.2580781120842220.503288231457018
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.118468 0.457371
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB04716 2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE experimental unknown unknown
DB08183 3-{(3R,4R)-4-methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}-3-oxopropanenitrile experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3LXN X-ray 2.5Å A=888-1182.
3LXP X-ray 1.6Å A=888-1182.
3NYX X-ray 2.5Å A=885-1176.
3NZ0 X-ray 2.0Å A=885-1176.
3ZON X-ray 2.1Å A=541-873.
4GFO X-ray 2.3Å A=884-1176.
4GIH X-ray 2.0Å A=885-1176.
4GII X-ray 2.3Å A=885-1176.
4GJ2 X-ray 2.4Å A=885-1176.
4GJ3 X-ray 2.5Å A=885-1176.
4GVJ X-ray 2.0Å A=885-1176.
4OLI X-ray 2.8Å A=566-1187.
4PO6 X-ray 1.9Å A=23-583.
4PY1 X-ray 2.1Å A=888-1182.
4WOV X-ray 1.8Å A/B=575-869.
5C01 X-ray 2.1Å A/B=556-871.
5C03 X-ray 1.9Å A/B=556-871.
5F1Z X-ray 2.6Å A=884-1176.
5F20 X-ray 2.9Å A=884-1176.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04380 Osteoclast differentiation - Homo sapiens (human)
hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04658 Th1 and Th2 cell differentiation - Homo sapiens (human)
hsa04659 Th17 cell differentiation - Homo sapiens (human)
hsa05145 Toxoplasmosis - Homo sapiens (human)
hsa05160 Hepatitis C - Homo sapiens (human)
hsa05162 Measles - Homo sapiens (human)
hsa05164 Influenza A - Homo sapiens (human)
hsa05168 Herpes simplex infection - Homo sapiens (human)
hsa05169 Epstein-Barr virus infection - Homo sapiens (human)