Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002979
UniProt IDP10600
Primary gene name(s)TGFB3
Synonym gene name(s)unknown
Protein nameTransforming growth factor beta-3
Protein functionInvolved in embryogenesis and cell differentiation.
Subcellular locationSecreted.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P10600
Gene Ontology
(Biological Process)
Complete annatation
activation of MAPK activity [GO:0000187];
aging [GO:0007568];
cell-cell junction organization [GO:0045216];
cell growth [GO:0016049];
detection of hypoxia [GO:0070483];
digestive tract development [GO:0048565];
embryonic neurocranium morphogenesis [GO:0048702];
face morphogenesis [GO:0060325];
female pregnancy [GO:0007565];
frontal suture morphogenesis [GO:0060364];
inner ear development [GO:0048839];
in utero embryonic development [GO:0001701];
lung alveolus development [GO:0048286];
mammary gland development [GO:0030879];
negative regulation of cell proliferation [GO:0008285];
negative regulation of DNA replication [GO:0008156];
negative regulation of macrophage cytokine production [GO:0010936];
negative regulation of neuron apoptotic process [GO:0043524];
negative regulation of transforming growth factor beta receptor signaling pathway [GO:0030512];
negative regulation of vascular smooth muscle cell proliferation [GO:1904706];
odontogenesis [GO:0042476];
ossification involved in bone remodeling [GO:0043932];
palate development [GO:0060021];
platelet degranulation [GO:0002576];
positive regulation of apoptotic process [GO:0043065];
positive regulation of bone mineralization [GO:0030501];
positive regulation of cell division [GO:0051781];
positive regulation of collagen biosynthetic process [GO:0032967];
positive regulation of DNA replication [GO:0045740];
positive regulation of epithelial to mesenchymal transition [GO:0010718];
positive regulation of filopodium assembly [GO:0051491];
positive regulation of occluding junction disassembly [GO:1905075];
positive regulation of pathway-restricted SMAD protein phosphorylation [GO:0010862];
positive regulation of protein secretion [GO:0050714];
positive regulation of SMAD protein import into nucleus [GO:0060391];
positive regulation of stress fiber assembly [GO:0051496];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
regulation of apoptotic process [GO:0042981];
regulation of cell proliferation [GO:0042127];
regulation of MAPK cascade [GO:0043408];
response to estrogen [GO:0043627];
response to hypoxia [GO:0001666];
response to laminar fluid shear stress [GO:0034616];
response to progesterone [GO:0032570];
salivary gland morphogenesis [GO:0007435];
SMAD protein import into nucleus [GO:0007184];
SMAD protein signal transduction [GO:0060395];
transforming growth factor beta receptor signaling pathway [GO:0007179];
uterine wall breakdown [GO:0042704];
wound healing [GO:0042060]
Gene Ontology
(Molecular Function)
Complete annatation
cytokine activity [GO:0005125];
identical protein binding [GO:0042802];
transforming growth factor beta binding [GO:0050431];
type III transforming growth factor beta receptor binding [GO:0034714];
type II transforming growth factor beta receptor binding [GO:0005114];
type I transforming growth factor beta receptor binding [GO:0034713]
Gene Ontology
(Cellular Component)
Complete annatation
cell surface [GO:0009986];
extracellular matrix [GO:0031012];
extracellular region [GO:0005576];
extracellular space [GO:0005615];
neuronal cell body [GO:0043025];
nucleus [GO:0005634];
plasma membrane [GO:0005886];
platelet alpha granule lumen [GO:0031093];
T-tubule [GO:0030315]
Protein-protein interaction112901
Phylogenetic treeP10600
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.3594555154724390.3024217260895640.420966206863456
AZA vs. DISU-0.02592578230008230.9256164495781430.995042856396371
AZA vs. IL7-0.2240995036108720.3261223568884170.999311006273513
AZA vs. SAHA-0.02089807911381290.9562868270510260.990779256780515
DISU vs. CD30.3202615905400770.3996025911347820.533345976515469
DISU vs. IL7-0.2077596937963220.4531084165347060.797319551305746
DISU vs. SAHA0.006687638560700550.986101123918880.998356176177713
DMSO vs. AZA0.1385003261562840.4987996999879661
DMSO vs. CD30.4866606777318530.1507798484096780.238127520315736
DMSO vs. DISU0.1632404210646690.5401615070097210.921635859189505
DMSO vs. IL7-0.3553922503409030.09542589448158740.566734231787423
DMSO vs. SAHA-0.1666958970040680.6586482298463610.892524396635398
HIV vs. Mock in Activation-0.06846553682538240.9164892242997060.999983755607037
HIV vs. Mock in Latency-0.1204319047062150.5154555238762130.999834320637052
IL7 vs. CD30.1397292537144960.6833952931413220.784241764257021
SAHA vs. CD30.3138415478593130.4107534276524150.526383668688519
SAHA vs. IL70.1989318657895970.6027223991016010.798970624938181
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.105127 0.777057
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB03316 1,4-Diethylene Dioxide experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1KTZ X-ray 2.1Å A=301-412.
1TGJ X-ray 2.0Å A=301-412.
1TGK X-ray 3.3Å A=301-412.
2PJY X-ray 3.0Å A=301-412.
3EO1 X-ray 3.1Å C/F/I/L=301-412.
4UM9 X-ray 2.5Å E/F=259-269.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu interacts with 24551192
Vpu activates 24551192
HIV-1 virus replication enhanced by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04010 MAPK signaling pathway - Homo sapiens (human)
hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
hsa04068 FoxO signaling pathway - Homo sapiens (human)
hsa04110 Cell cycle - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)
hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
hsa04390 Hippo signaling pathway - Homo sapiens (human)
hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
hsa05140 Leishmaniasis - Homo sapiens (human)
hsa05142 Chagas disease (American trypanosomiasis) - Homo sapiens (human)
hsa05144 Malaria - Homo sapiens (human)
hsa05145 Toxoplasmosis - Homo sapiens (human)
hsa05146 Amoebiasis - Homo sapiens (human)
hsa05152 Tuberculosis - Homo sapiens (human)
hsa05161 Hepatitis B - Homo sapiens (human)
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05200 Pathways in cancer - Homo sapiens (human)
hsa05210 Colorectal cancer - Homo sapiens (human)
hsa05211 Renal cell carcinoma - Homo sapiens (human)
hsa05212 Pancreatic cancer - Homo sapiens (human)
hsa05220 Chronic myeloid leukemia - Homo sapiens (human)
hsa05321 Inflammatory bowel disease (IBD) - Homo sapiens (human)
hsa05323 Rheumatoid arthritis - Homo sapiens (human)
hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
hsa05414 Dilated cardiomyopathy - Homo sapiens (human)
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