Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002978
UniProt IDP02786
Primary gene name(s)TFRC
Synonym gene name(s)unknown
Protein nameTransferrin receptor protein 1
Protein functionCellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system, By similarity. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake, PubMed:26642240. {ECO:0000250, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:3568132}.; FUNCTION:, Microbial infection Acts as a receptor for new-world arenaviruses: Guanarito, Junin and Machupo virus. {ECO:0000269|PubMed:17287727, ECO:0000269|PubMed:18268337}.
Subcellular locationCell membrane {ECO:0000269|PubMed:17081065};
Single-pass type II membrane protein {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:17081065}.;
SUBCELLULAR LOCATION: Transferrin receptor protein 1, serum form: Secreted {ECO:0000269|PubMed:17081065}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P02786
Gene Ontology
(Biological Process)
Complete annatation
cellular iron ion homeostasis [GO:0006879];
cellular response to drug [GO:0035690];
iron ion import [GO:0097286];
osteoclast differentiation [GO:0030316];
positive regulation of B cell proliferation [GO:0030890];
positive regulation of bone resorption [GO:0045780];
positive regulation of isotype switching [GO:0045830];
positive regulation of T cell proliferation [GO:0042102];
receptor internalization [GO:0031623];
transferrin transport [GO:0033572]
Gene Ontology
(Molecular Function)
Complete annatation
double-stranded RNA binding [GO:0003725];
glycoprotein binding [GO:0001948];
identical protein binding [GO:0042802];
poly(A RNA binding [GO:0044822];
protein homodimerization activity [GO:0042803];
transferrin receptor activity [GO:0004998];
transferrin transmembrane transporter activity [GO:0033570];
virus receptor activity [GO:0001618]
Gene Ontology
(Cellular Component)
Complete annatation
basolateral plasma membrane [GO:0016323];
blood microparticle [GO:0072562];
cell surface [GO:0009986];
coated pit [GO:0005905];
cytoplasmic, membrane-bounded vesicle [GO:0016023];
endosome [GO:0005768];
external side of plasma membrane [GO:0009897];
extracellular exosome [GO:0070062];
extracellular region [GO:0005576];
extracellular space [GO:0005615];
extracellular vesicle [GO:1903561];
HFE-transferrin receptor complex [GO:1990712];
integral component of plasma membrane [GO:0005887];
intracellular membrane-bounded organelle [GO:0043231];
melanosome [GO:0042470];
membrane [GO:0016020];
mitochondrion [GO:0005739];
perinuclear region of cytoplasm [GO:0048471];
plasma membrane [GO:0005886];
recycling endosome [GO:0055037];
recycling endosome membrane [GO:0055038]
Protein-protein interaction112895
Phylogenetic treeP02786
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: 2.289484821; Folds changes 16h: 3.212514576; Tested: untested;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD33.2299493925290500
AZA vs. DISU-0.3812557562347140.1377851491793710.710950620469254
AZA vs. IL71.09414299421631.18777746527243e-078.52541415907209e-05
AZA vs. SAHA-0.7191418169603640.003359997246223930.0475573694737836
DISU vs. CD3-3.6234902743399600
DISU vs. IL71.466665024496591.31768339572957e-083.54715664118274e-06
DISU vs. SAHA-0.3373185450416110.2512228916510280.62945639236453
DMSO vs. AZA0.01013529254197780.959473380454321
DMSO vs. CD3-3.2309645793475500
DMSO vs. DISU0.3895825544332950.1157613091127960.59136370451859
DMSO vs. IL71.091306013786051.79708572467518e-081.52246690518498e-05
DMSO vs. SAHA-0.7367676277001620.001877637776255380.0280177019068761
HIV vs. Mock in Activation0.04671276350593560.9405497011130320.999983755607037
HIV vs. Mock in Latency0.01382294922921470.9332356613528570.999834320637052
IL7 vs. CD3-2.127376109200712.22142415573501e-104.44078598135196e-09
SAHA vs. CD3-3.9752360601741800
SAHA vs. IL7-1.817073052537534.27102797573298e-131.46321535695907e-10
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.046464878
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.675182 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.001 0.975 0.887 0.798 0.802
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
0.53 <0.0001 0.2 0.0789 -1.06 <0.0001 T-cell activation at 20 hpi
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB05260 Gallium nitrate approved, investigational yes unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1CX8 X-ray 3.2Å A/B/C/D/E/F/G/H=122-760.
1DE4 X-ray 2.8Å C/F/I=121-760.
1SUV EM 7.5Å A/B=122-760.
2NSU EM 27.0Å A/B=122-760.
3KAS X-ray 2.4Å A=121-760.
3S9L X-ray 3.2Å A/B=120-760.
3S9M X-ray 3.3Å A/B=120-760.
3S9N X-ray 3.2Å A/B=120-760.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu co-localizes with 20880565
Envelope surface glycoprotein gp120 downregulates 9341758
Nef modulates 15569681
Envelope surface glycoprotein gp160; precursor interacts with 23861967
Vpr upregulates 23874603
Nef downregulates 10451539
Vpu downregulates 25275127
Envelope surface glycoprotein gp120 upregulates 15784911
Pr55(Gag) interacts with 23861967
Tat interacts with 25496916

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
hsa04144 Endocytosis - Homo sapiens (human)
hsa04145 Phagosome - Homo sapiens (human)
hsa04640 Hematopoietic cell lineage - Homo sapiens (human)