Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002769
UniProt IDQ92922
Primary gene name(s)SMARCC1
Synonym gene name(s)BAF155
Protein nameSWI/SNF complex subunit SMARCC1
Protein functionInvolved in transcriptional activation and repression of select genes by chromatin remodeling, alteration of DNA-nucleosome topology. May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin remodeling complex, npBAF complex and the neuron-specific chromatin remodeling complex, nBAF complex. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes, nBAF. The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth, By similarity. {ECO:0000250, ECO:0000269|PubMed:11018012}.
Subcellular locationNucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92922
Gene Ontology
(Biological Process)
Complete annatation
animal organ morphogenesis [GO:0009887];
ATP-dependent chromatin remodeling [GO:0043044];
chromatin remodeling [GO:0006338];
covalent chromatin modification [GO:0016569];
insulin receptor signaling pathway [GO:0008286];
negative regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032435];
nervous system development [GO:0007399];
nucleosome disassembly [GO:0006337];
positive regulation of transcription, DNA-templated [GO:0045893];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
prostate gland development [GO:0030850];
regulation of transcription from RNA polymerase II promoter [GO:0006357];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
chromatin binding [GO:0003682];
DNA binding [GO:0003677];
protein N-terminus binding [GO:0047485];
transcription coactivator activity [GO:0003713]
Gene Ontology
(Cellular Component)
Complete annatation
nBAF complex [GO:0071565];
npBAF complex [GO:0071564];
nuclear chromatin [GO:0000790];
nucleoplasm [GO:0005654];
protein complex [GO:0043234];
SWI/SNF complex [GO:0016514];
XY body [GO:0001741]
Protein-protein interaction112483
Phylogenetic treeQ92922
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.103324172229530.0008679468688571610.00320708389492894
AZA vs. DISU-0.02603958130608550.9180221414952480.994271142470137
AZA vs. IL70.09863358081374040.607553244927650.999311006273513
AZA vs. SAHA-0.3561439894401240.1446741331232990.484384314018191
DISU vs. CD3-1.141495926450070.001973146803542770.00740802364049905
DISU vs. IL70.1156639786972560.6457791069576650.896998068495974
DISU vs. SAHA-0.3291164074199060.2586488319549870.636721404511744
DMSO vs. AZA-0.02386138630864420.8865721161589991
DMSO vs. CD3-1.139118671038150.000441368229740280.00167359989454753
DMSO vs. DISU0.0001339817435282690.9995622417300140.999828688118659
DMSO vs. IL70.1298808834162950.4694861327693160.877802004454825
DMSO vs. SAHA-0.3390008479666210.1505330284461440.467597503946166
HIV vs. Mock in Activation0.1586989251368760.7987398970630050.999983755607037
HIV vs. Mock in Latency-0.01457883480183040.9294707298604910.999834320637052
IL7 vs. CD3-0.9969138469109340.002175648949023890.00827951678946173
SAHA vs. CD3-1.484410885579124.07685896099963e-050.000217557593988188
SAHA vs. IL7-0.4585437670749790.05990764990750770.206883829256763
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.245426 0.0680936
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.976 1.033 0.94 0.87 1.116
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2YUS NMR - A=610-675.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat induces phosphorylation of 21699904

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found