Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002762
UniProt IDQ7Z7L1
Primary gene name(s)SLFN11
Synonym gene name(s)unknown
Protein nameSchlafen family member 11
Protein functionInterferon, IFN-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1, HIV-1 by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage. {ECO:0000269|PubMed:22927417, ECO:0000269|PubMed:23000900}.
Subcellular locationNucleus {ECO:0000269|PubMed:22927417}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q7Z7L1
Gene Ontology
(Biological Process)
Complete annatation
defense response to virus [GO:0051607];
negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]
Gene Ontology
(Molecular Function)
Complete annatation
ATP binding [GO:0005524];
tRNA binding [GO:0000049]
Gene Ontology
(Cellular Component)
Complete annatation
aggresome [GO:0016235];
cytoplasm [GO:0005737];
nucleoplasm [GO:0005654];
nucleus [GO:0005634]
Protein-protein interaction124851
Phylogenetic treeQ7Z7L1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.1784818269126180.676387336684410.766219142944511
AZA vs. DISU0.3996357621761970.3446597608943820.883324902695907
AZA vs. IL7-0.01036941403141390.9781398333527740.999311006273513
AZA vs. SAHA0.5732569401674710.08383118150345250.361333563830555
DISU vs. CD30.2073204602103570.6565942338360490.755880669073209
DISU vs. IL7-0.4172508671967550.3447105823833720.725928220383342
DISU vs. SAHA0.1729047705862540.6705540632228670.899823727791989
DMSO vs. AZA0.03706127392566030.9151331491463151
DMSO vs. CD3-0.1623033023985060.6924316022772110.773791416683198
DMSO vs. DISU-0.367043103076190.3732047943186880.85279700536507
DMSO vs. IL7-0.03883578880262170.9157457635239340.982502110541903
DMSO vs. SAHA0.5297390106471120.09512308887227330.362386267035903
HIV vs. Mock in Activation-0.236394079573210.7744587144365750.999983755607037
HIV vs. Mock in Latency-0.1954411596188240.6823068368686510.999834320637052
IL7 vs. CD3-0.1768163160530440.6949562946236820.793085722960536
SAHA vs. CD30.3672760997991070.381408166055560.497991774602088
SAHA vs. IL70.5775749258498190.1028442219632620.292250164958307
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.319537 0.0141633
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found