Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002761
UniProt IDQ96BD0
Primary gene name(s)SLCO4A1
Synonym gene name(s)OATP1, OATP4A1, OATPE, SLC21A12
Protein nameSolute carrier organic anion transporter family member 4A1
Protein functionMediates the Na(+-independent transport of organic anions such as the thyroid hormones T3, triiodo-L-thyronine, T4, thyroxine and rT3, and of estrone-3-sulfate and taurocholate.
Subcellular locationCell membrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q96BD0
Gene Ontology
(Biological Process)
Complete annatation
sodium-independent organic anion transport [GO:0043252];
thyroid hormone transport [GO:0070327]
Gene Ontology
(Molecular Function)
Complete annatation
sodium-independent organic anion transmembrane transporter activity [GO:0015347];
thyroid hormone transmembrane transporter activity [GO:0015349]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interaction118180
Phylogenetic treeQ96BD0
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.021739283039733.31141647436084e-094.28041759018581e-08
AZA vs. DISU-0.4715263445295050.1531556812540550.735170045791188
AZA vs. IL71.000079083232786.66960166983976e-070.000297693569197755
AZA vs. SAHA-0.494904518563210.09077365409925850.379452586500514
DISU vs. CD3-2.507208713208148.33599855809553e-112.06672437935414e-09
DISU vs. IL71.462230593698566.48063966768309e-060.000622265241976577
DISU vs. SAHA-0.02089971397462870.9567406000889980.990061919404485
DMSO vs. AZA0.172059184564460.3349458794444241
DMSO vs. CD3-1.864372836863871.90658382415165e-081.92253583071249e-07
DMSO vs. DISU0.640720485386980.039354413624390.398866336139429
DMSO vs. IL70.8361014443255487.8855235250419e-060.00165103148805565
DMSO vs. SAHA-0.6715587903909720.0132391150974550.108203201536738
HIV vs. Mock in Activation0.1459281478798070.8149400244341370.999983755607037
HIV vs. Mock in Latency-0.3599203090393490.04756816784646540.849576495400024
IL7 vs. CD3-1.014768782755250.001865831146608430.00727273671394593
SAHA vs. CD3-2.541093278203451.49641410374102e-113.75223969107773e-10
SAHA vs. IL7-1.49698640815291.9440132581483e-071.13581611834603e-05
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.30001 0.084435
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00279 Liothyronine approved, vet_approved unknown substrate
DB04348 Taurocholic Acid experimental unknown inhibitor
DB00917 Dinoprostone approved unknown substrate
DB01053 Benzylpenicillin approved, vet_approved unknown substrate
DB00286 Conjugated Equine Estrogens approved unknown substrate
DB00390 Digoxin approved unknown substrate
DB01583 Liotrix approved unknown substrate
DB00783 Estradiol approved, investigational, vet_approved unknown unknown
DB00451 Levothyroxine approved unknown unknown
DB00509 Dextrothyroxine approved unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found