Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002760
UniProt IDP46721
Primary gene name(s)SLCO1A2
Synonym gene name(s)OATP, OATP1, OATP1A2, SLC21A3
Protein nameSolute carrier organic anion transporter family member 1A2
Protein functionMediates the Na(+-independent transport of organic anions such as sulfobromophthalein, BSP and conjugated, taurocholate and unconjugated, cholate bile acids, By similarity. Selectively inhibited by the grapefruit juice component naringin. {ECO:0000250, ECO:0000269|PubMed:17301733}.
Subcellular locationCell membrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P46721
Gene Ontology
(Biological Process)
Complete annatation
bile acid and bile salt transport [GO:0015721];
bile acid metabolic process [GO:0008206];
organic anion transport [GO:0015711];
sodium-independent organic anion transport [GO:0043252]
Gene Ontology
(Molecular Function)
Complete annatation
bile acid transmembrane transporter activity [GO:0015125];
organic anion transmembrane transporter activity [GO:0008514];
sodium-independent organic anion transmembrane transporter activity [GO:0015347]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interactionunknown
Phylogenetic treeP46721
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3unknownunknownunknown
AZA vs. DISUunknownunknownunknown
AZA vs. IL7unknownunknownunknown
AZA vs. SAHAunknownunknownunknown
DISU vs. CD3unknownunknownunknown
DISU vs. IL7unknownunknownunknown
DISU vs. SAHAunknownunknownunknown
DMSO vs. AZAunknownunknownunknown
DMSO vs. CD3unknownunknownunknown
DMSO vs. DISUunknownunknownunknown
DMSO vs. IL7unknownunknownunknown
DMSO vs. SAHAunknownunknownunknown
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latencyunknownunknownunknown
IL7 vs. CD3unknownunknownunknown
SAHA vs. CD3unknownunknownunknown
SAHA vs. IL7unknownunknownunknown
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
NOTEST -0.719934 1
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB04348 Taurocholic Acid experimental unknown substrate
DB01586 Ursodeoxycholic acid approved, investigational unknown substrate
DB02659 Cholic Acid approved unknown substrate
DB00624 Testosterone approved, investigational unknown inhibitor
DB00669 Sumatriptan approved, investigational unknown inducer
DB01183 Naloxone approved, vet_approved unknown inhibitor
DB00286 Conjugated Equine Estrogens approved unknown substrate
DB00908 Quinidine approved unknown inhibitor
DB01045 Rifampicin approved unknown inhibitor
DB01234 Dexamethasone approved, investigational, vet_approved unknown inhibitor
DB00661 Verapamil approved unknown inhibitor
DB01232 Saquinavir approved, investigational unknown inhibitor
DB00503 Ritonavir approved, investigational unknown inhibitor
DB00220 Nelfinavir approved unknown inhibitor
DB00227 Lovastatin approved, investigational unknown inhibitor
DB01026 Ketoconazole approved, investigational unknown inhibitor
DB00224 Indinavir approved unknown inhibitor
DB00199 Erythromycin approved, vet_approved unknown substrate
DB01032 Probenecid approved unknown inhibitor
DB01124 Tolbutamide approved unknown inhibitor
DB00468 Quinine approved unknown inhibitor
DB00788 Naproxen approved, vet_approved unknown inhibitor
DB01009 Ketoprofen approved, vet_approved unknown inhibitor
DB00328 Indomethacin approved, investigational unknown substrate
DB01050 Ibuprofen approved unknown inhibitor
DB01016 Glyburide approved unknown inhibitor
DB00091 Cyclosporine approved, investigational, vet_approved unknown inhibitor
DB02123 Glycochenodeoxycholic Acid experimental unknown substrate
DB03619 Deoxycholic Acid approved unknown substrate
DB00421 Spironolactone approved unknown inhibitor
DB00741 Hydrocortisone approved, vet_approved unknown inhibitor
DB04630 Aldosterone experimental unknown inhibitor
DB00655 Estrone approved unknown inhibitor
DB04573 Estriol approved, vet_approved unknown inhibitor
DB00783 Estradiol approved, investigational, vet_approved unknown inhibitor
DB00635 Prednisone approved, vet_approved unknown inhibitor
DB00860 Prednisolone approved, vet_approved unknown inhibitor
DB01396 Digitoxin approved unknown inhibitor
DB01092 Ouabain approved unknown substrate
DB00641 Simvastatin approved unknown inhibitor
DB00175 Pravastatin approved unknown inhibitor
DB01076 Atorvastatin approved unknown inhibitor
DB00584 Enalapril approved, vet_approved unknown substrate
DB00917 Dinoprostone approved unknown substrate
DB00279 Liothyronine approved, vet_approved unknown substrate
DB00950 Fexofenadine approved unknown substrate
DB00728 Rocuronium approved unknown substrate
DB00390 Digoxin approved unknown substrate
DB00563 Methotrexate approved unknown substrate
DB00887 Bumetanide approved unknown substrate
DB00345 Aminohippuric acid approved unknown substrate
DB01583 Liotrix approved unknown substrate
DB06710 Methyltestosterone approved unknown inhibitor
DB02691 N-Cholylglycine experimental unknown unknown
DB05804 dehydroepiandrosterone sulfate investigational unknown unknown
DB00451 Levothyroxine approved unknown unknown
DB00291 Chlorambucil approved unknown unknown
DB08834 Tauroursodeoxycholic acid approved, investigational unknown unknown
DB08836 Temocapril experimental, investigational unknown unknown
DB01098 Rosuvastatin approved unknown unknown
DB08893 Mirabegron approved unknown substrate
DB01045 Rifampicin approved unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04976 Bile secretion - Homo sapiens (human)