Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002753
UniProt IDQ92536
Primary gene name(s)SLC7A6
Synonym gene name(s)KIAA0245
Protein nameY+L amino acid transporter 2
Protein functionInvolved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires coexpression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells, HUVECs via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial, RPE cells. {ECO:0000269|PubMed:10903140, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:14603368, ECO:0000269|PubMed:15280038, ECO:0000269|PubMed:16785209, ECO:0000269|PubMed:17197568, ECO:0000269|PubMed:17329401, ECO:0000269|PubMed:9829974}.
Subcellular locationBasolateral cell membrane {ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209};
Multi-pass membrane protein {ECO:0000269|PubMed:15756301, ECO:0000269|PubMed:16785209}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q92536
Gene Ontology
(Biological Process)
Complete annatation
amino acid transport [GO:0006865];
cellular amino acid metabolic process [GO:0006520];
leukocyte migration [GO:0050900];
protein complex assembly [GO:0006461];
transport [GO:0006810]
Gene Ontology
(Molecular Function)
Complete annatation
amino acid transmembrane transporter activity [GO:0015171];
antiporter activity [GO:0015297];
L-amino acid transmembrane transporter activity [GO:0015179]
Gene Ontology
(Cellular Component)
Complete annatation
basolateral plasma membrane [GO:0016323];
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interaction114519
Phylogenetic treeQ92536
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.02825450626227020.9370462653682630.959547681353153
AZA vs. DISU-0.09128229410299960.7180943780289990.973374730783303
AZA vs. IL70.02388542773385130.9008396091906140.999311006273513
AZA vs. SAHA-0.4901006422591140.04459239634456010.251472421435802
DISU vs. CD3-0.1326383635183690.7254695704531730.807198064949744
DISU vs. IL70.1059737123295660.674156728651470.91090012408541
DISU vs. SAHA-0.3968671999293440.1741047037193770.538053990825724
DMSO vs. AZA-0.01175528822618580.9438590143627661
DMSO vs. CD3-0.05288032637298340.8810763619222430.91825772344231
DMSO vs. DISU0.07756408878760670.7507542497447780.969857060964769
DMSO vs. IL70.04295814758962010.810603595296230.962475569829797
DMSO vs. SAHA-0.483973359498290.04011520660756440.222434245321046
HIV vs. Mock in Activation0.4677203289900430.5416053385748150.999983755607037
HIV vs. Mock in Latency-0.01199397528672510.9420173079826630.999834320637052
IL7 vs. CD30.001873981786742790.9957637270411190.997226074053464
SAHA vs. CD3-0.5425185942913210.1314374671971710.216903485617758
SAHA vs. IL7-0.5171110903952720.03379901125000370.141366896665526
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.080047 0.654388
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found