Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002735
UniProt IDQ9NP59
Primary gene name(s)SLC40A1
Synonym gene name(s)FPN1, IREG1, SLC11A3
Protein nameSolute carrier family 40 member 1
Protein functionMay be involved in iron export from duodenal epithelial cell and also in transfer of iron between maternal and fetal circulation. Mediates iron efflux in the presence of a ferroxidase, hephaestin and/or ceruloplasmin.
Subcellular locationCell membrane {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:23219802};
Multi-pass membrane protein {ECO:0000269|PubMed:10882071, ECO:0000269|PubMed:23219802}. Note=Localized to the basolateral membrane of polarized epithelial cells.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NP59
Gene Ontology
(Biological Process)
Complete annatation
cellular iron ion homeostasis [GO:0006879];
endothelium development [GO:0003158];
ferrous iron export [GO:1903988];
iron ion transmembrane transport [GO:0034755];
lymphocyte homeostasis [GO:0002260];
multicellular organismal iron ion homeostasis [GO:0060586];
negative regulation of apoptotic process [GO:0043066];
positive regulation of transcription from RNA polymerase II promoter [GO:0045944];
regulation of transcription from RNA polymerase II promoter in response to iron [GO:0034395];
spleen trabecula formation [GO:0060345]
Gene Ontology
(Molecular Function)
Complete annatation
ferrous iron transmembrane transporter activity [GO:0015093];
iron channel activity [GO:0097689];
iron ion transmembrane transporter activity [GO:0005381];
peptide hormone binding [GO:0017046];
receptor activity [GO:0004872]
Gene Ontology
(Cellular Component)
Complete annatation
basolateral plasma membrane [GO:0016323];
cytoplasm [GO:0005737];
integral component of membrane [GO:0016021];
integral component of plasma membrane [GO:0005887];
intracellular [GO:0005622];
multivesicular body [GO:0005771];
plasma membrane [GO:0005886];
synaptic vesicle [GO:0008021]
Protein-protein interactionunknown
Phylogenetic treeQ9NP59
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-3.620901875305732.22044604925031e-168.94827883804832e-15
AZA vs. DISU-0.9852826568463360.0001284601306613680.0190164443725715
AZA vs. IL70.9462685284991810.0008352097792785340.0691709725443151
AZA vs. SAHA-0.04722907159363370.8693955675965320.969754978981066
DISU vs. CD32.625571866089233.19841930718212e-118.73423417327234e-10
DISU vs. IL71.922482728358091.92734717074927e-131.93698390660302e-10
DISU vs. SAHA0.9378476380531840.001501822439014310.0273357077033631
DMSO vs. AZA-0.0007538963151594050.9979652606832541
DMSO vs. CD33.6062647062723300
DMSO vs. DISU0.9820035266099447.56560174195453e-050.0123927845925277
DMSO vs. IL70.9544316869375040.0002120565634595730.0196119797187304
DMSO vs. SAHA-0.05344219086415440.840070130196130.956896450168988
HIV vs. Mock in Activation0.1333520289752490.8610382330583690.999983755607037
HIV vs. Mock in Latency-0.2871533298397650.3416128992325140.999834320637052
IL7 vs. CD34.5778368001405900
SAHA vs. CD33.5478262479679400
SAHA vs. IL7-0.9971513514451495.7376121603836e-050.0012462358170839
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander -1.08 8.94E-10 5.19E-08
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.127923 0.429974
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04978 Mineral absorption - Homo sapiens (human)