Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002719
UniProt IDP11169
Primary gene name(s)SLC2A3
Synonym gene name(s)GLUT3
Protein nameSolute carrier family 2, facilitated glucose transporter member 3
Protein functionFacilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane, PubMed:9477959, PubMed:26176916. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate, PubMed:9477959, PubMed:26176916. Does not mediate fructose transport, PubMed:9477959, PubMed:26176916. {ECO:0000269|PubMed:26176916, ECO:0000269|PubMed:9477959}.
Subcellular locationCell membrane {ECO:0000269|PubMed:9477959, ECO:0000305|PubMed:26176916};
Multi-pass membrane protein {ECO:0000269|PubMed:26176916}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P11169
Gene Ontology
(Biological Process)
Complete annatation
carbohydrate metabolic process [GO:0005975];
glucose transmembrane transport [GO:1904659];
glucose transport [GO:0015758];
L-ascorbic acid metabolic process [GO:0019852]
Gene Ontology
(Molecular Function)
Complete annatation
dehydroascorbic acid transporter activity [GO:0033300];
D-glucose transmembrane transporter activity [GO:0055056];
glucose binding [GO:0005536];
glucose transmembrane transporter activity [GO:0005355]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
integral component of membrane [GO:0016021];
integral component of plasma membrane [GO:0005887];
plasma membrane [GO:0005886]
Protein-protein interaction112406
Phylogenetic treeP11169
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.8808938712136510.008844415462650690.0235429816027633
AZA vs. DISU0.1661397646068880.5106978723208950.938109377229618
AZA vs. IL70.07451698079141780.6977884539891770.999311006273513
AZA vs. SAHA0.1589830250224240.5149022433391150.830669102528198
DISU vs. CD31.034060185252710.005670862004349520.0180114989156268
DISU vs. IL7-0.1007120292814730.6888121597373510.91804885048312
DISU vs. SAHA-0.005113035471211290.9859987361598590.998356176177713
DMSO vs. AZA0.05826169129346210.7274500905806611
DMSO vs. CD30.9270293696316670.005471190378008140.0148110481661622
DMSO vs. DISU-0.1098022321127230.6521716354893280.949713766615536
DMSO vs. IL70.02351475496741330.8957469491729130.977585264517604
DMSO vs. SAHA0.0947795510644310.6879279019389650.903270819603958
HIV vs. Mock in Activation0.06605545761231430.9318052001885260.999983755607037
HIV vs. Mock in Latency0.3847509235968670.2055861205849980.999834320637052
IL7 vs. CD30.9625793889297760.004099802207598980.0142191253279198
SAHA vs. CD31.015957454067020.00606673672232250.0168340494209906
SAHA vs. IL70.08140838679377630.7382565326227680.881056555732713
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.208128 0.133238
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.12 0.931 1.093 1.125 0.81
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
202497_x_at 2.04 No downregulated in CD8+ cells
202498_s_at 1.71 No downregulated in CD8+ cells
202499_s_at 1.69 No downregulated in CD8+ cells
216236_s_at 2.17 No downregulated in CD8+ cells
222088_s_at 1.58 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
4ZW9 X-ray 1.5Å A=1-496.
4ZWB X-ray 2.4Å A=1-496.
4ZWC X-ray 2.6Å A/B=1-496.
5C65 X-ray 2.6Å A/B=1-474.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
HIV-1 virus replication enhanced by expression of human gene 18976975

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found