Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002715
UniProt IDQ6PCB7
Primary gene name(s)SLC27A1
Synonym gene name(s)ACSVL5, FATP1
Protein nameLong-chain fatty acid transport protein 1
Protein functionInvolved in translocation of long-chain fatty acids, LFCA across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids, By similarity. {ECO:0000250, ECO:0000269|PubMed:12235169}.
Subcellular locationCell membrane {ECO:0000269|PubMed:12235169};
Single-pass membrane protein {ECO:0000269|PubMed:12235169}. Endomembrane system {ECO:0000269|PubMed:12235169};
Single-pass membrane protein {ECO:0000269|PubMed:12235169}. Cytoplasm {ECO:0000250}. Note=Plasma membrane and intracellular membranes, at least in adipocytes. Predominantly cytoplasmic in myocytes, By similarity. {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q6PCB7
Gene Ontology
(Biological Process)
Complete annatation
adiponectin-activated signaling pathway [GO:0033211];
cardiolipin biosynthetic process [GO:0032049];
long-chain fatty acid transport [GO:0015909];
medium-chain fatty acid transport [GO:0001579];
negative regulation of phospholipid biosynthetic process [GO:0071072];
phosphatidic acid biosynthetic process [GO:0006654];
phosphatidylcholine biosynthetic process [GO:0006656];
phosphatidylethanolamine biosynthetic process [GO:0006646];
phosphatidylglycerol biosynthetic process [GO:0006655];
phosphatidylinositol biosynthetic process [GO:0006661];
phosphatidylserine biosynthetic process [GO:0006659];
positive regulation of heat generation [GO:0031652];
positive regulation of protein serine/threonine kinase activity [GO:0071902];
response to cold [GO:0009409];
response to insulin [GO:0032868]
Gene Ontology
(Molecular Function)
Complete annatation
fatty acid transporter activity [GO:0015245];
long-chain fatty acid-CoA ligase activity [GO:0004467];
nucleotide binding [GO:0000166];
very long-chain fatty acid-CoA ligase activity [GO:0031957]
Gene Ontology
(Cellular Component)
Complete annatation
caveola [GO:0005901];
endoplasmic reticulum [GO:0005783];
integral component of membrane [GO:0016021];
membrane [GO:0016020];
mitochondrial inner membrane [GO:0005743];
plasma membrane [GO:0005886]
Protein-protein interaction132009
Phylogenetic treeQ6PCB7
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.214443388816490.001682151261018120.00571150795360781
AZA vs. DISU-0.4035193938949840.2931486716388040.858710275220237
AZA vs. IL7-0.3416907668252820.4540986030218170.999311006273513
AZA vs. SAHA0.7789946956853240.0236838838270630.171722397695598
DISU vs. CD30.7985491468371450.03364161138926440.0786222713305071
DISU vs. IL70.0509409569982830.9096697449070050.982189124739072
DISU vs. SAHA1.186659721994090.0002866397598313420.00832359888327197
DMSO vs. AZA-0.0797097979300240.8342631902331271
DMSO vs. CD31.129552496989550.003038696773308370.0089972419201829
DMSO vs. DISU0.3235934329727160.383404449734240.857979524618098
DMSO vs. IL7-0.2553987277954240.5665241880646050.903127598508334
DMSO vs. SAHA0.8534260988696390.009393950994848520.0865058648330122
HIV vs. Mock in Activation0.5425505649439960.4076221889183280.999983755607037
HIV vs. Mock in Latency0.3049930348989760.07526274552651260.999834320637052
IL7 vs. CD30.8751927332477560.05138171115398580.112274052830056
SAHA vs. CD31.971423571496551.09857256958001e-071.14412499126267e-06
SAHA vs. IL71.119053163729350.008331261355345230.0552907005958756
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -1.05637 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef interacts with 25961023

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03320 PPAR signaling pathway - Homo sapiens (human)
hsa04931 Insulin resistance - Homo sapiens (human)