Protein Information (annotations from UniProt)
| Database ID | HIV0002700 |
| UniProt ID | Q08357 |
| Primary gene name(s) | SLC20A2 |
| Synonym gene name(s) | GLVR2, PIT2 |
| Protein name | Sodium-dependent phosphate transporter 2 |
| Protein function | Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus, A-MuLV, 10A1 murine leukemia virus, 10A1 MLV and some feline leukemia virus subgroup B, FeLV-B variants. {ECO:0000269|PubMed:11435563, ECO:0000269|PubMed:12205090, ECO:0000269|PubMed:15955065, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:8302848}. |
| Subcellular location | Cell membrane {ECO:0000269|PubMed:9151850}; Multi-pass membrane protein {ECO:0000269|PubMed:9151850}. |
| ECO code | Click here for more information. |
| Amino acid sequence FASTA format: Q08357 |
|
| Gene Ontology (Biological Process) Complete annatation | ion transport [GO:0006811]; transport [GO:0006810] |
| Gene Ontology (Molecular Function) Complete annatation | inorganic phosphate transmembrane transporter activity [GO:0005315]; receptor activity [GO:0004872]; sodium:inorganic phosphate symporter activity [GO:0015319]; sodium:phosphate symporter activity [GO:0005436]; sodium-dependent phosphate transmembrane transporter activity [GO:0015321]; virus receptor activity [GO:0001618] |
| Gene Ontology (Cellular Component) Complete annatation | extracellular exosome [GO:0070062]; integral component of plasma membrane [GO:0005887]; membrane [GO:0016020]; plasma membrane [GO:0005886] |
| Protein-protein interaction | 112463 |
| Phylogenetic tree | Q08357 |
| HIV replication factor status |
Zhou et al., Cell. Host. Microbe., 2008 unknown Brass et al., Science, 2008 unknown Smith et al., J. Immunol, 2010 unknown |
| Interferon-stimulated gene status |
Lu et al., J. Virol., 2011 Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown; Schoggins JW and Rice CM, Curr. Opin. Virol., 2011 Targeted viruses: unknown Viral life cycle: unknown Mechanism related to antiviral activity: unknown |
| Anti-viral restriction factor |
Liu et al., Retrovirology, 2011 unknown (Triplicates) |
Gene Expression Profile top
Up-regulated; 
Down-regulated
For brief introduction to each study, please go to the help page.
Gene expression during HIV latency
| (1). Mohammadi et al., PLoS Pathog., 2014 Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model DMSO: Dimethyl suloxyde (negative control) - 0.0033% final SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies IL7: Interleukin-7 based stimulation DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM |
|||
| Experimental Condition | Log2 Fold Change | P value | Adjusted P value |
| AZA vs. CD3 | 0.203715097692711 | 0.53519565984064 | 0.649369585019974 |
| AZA vs. DISU | -0.286155999063771 | 0.260420811039272 | 0.840416036310424 |
| AZA vs. IL7 | 0.207643822879273 | 0.283794784187984 | 0.999311006273513 |
| AZA vs. SAHA | -0.333853225973303 | 0.174588159858595 | 0.532741279698068 |
| DISU vs. CD3 | -0.502262038870818 | 0.168166868506158 | 0.278964165936154 |
| DISU vs. IL7 | 0.485126650190968 | 0.0555519737436611 | 0.309788752488253 |
| DISU vs. SAHA | -0.0468226105695668 | 0.872896342129123 | 0.9666253338219 |
| DMSO vs. AZA | 0.0328034956550799 | 0.846453835859102 | 1 |
| DMSO vs. CD3 | -0.184662923004381 | 0.564828464809525 | 0.666651584327444 |
| DMSO vs. DISU | 0.316482515280556 | 0.196915205738863 | 0.713677194394938 |
| DMSO vs. IL7 | 0.182420313169902 | 0.314033389737644 | 0.795366359878558 |
| DMSO vs. SAHA | -0.373018115292261 | 0.116430528467267 | 0.405703000602462 |
| HIV vs. Mock in Activation | 0.0322976041677008 | 0.958641051302608 | 0.999983755607037 |
| HIV vs. Mock in Latency | -0.0751909676198777 | 0.651870808908362 | 0.999834320637052 |
| IL7 vs. CD3 | 0.0123221302396844 | 0.96948975655575 | 0.981876875090997 |
| SAHA vs. CD3 | -0.562473182141254 | 0.114968523315425 | 0.194912323811841 |
| SAHA vs. IL7 | -0.545148248821555 | 0.0264464509054302 | 0.120512031725651 |
| (2). Iglesias-Ussel et al., J. Virol., 2013 Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model |
|||
| Log2 Fold Change | P Value | ||
| unknown | unknown | ||
Gene expression during HIV infection and replication
| (1). Imbeault et al., PloS Pathog., 2012 Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells |
|||||
| Experiment type | Log2 Fold Change | P Value | Adjusted P Value | ||
| Infected vs. Mock | unknown | unknown | unknown | ||
| Infected vs. Bystander | unknown | unknown | unknown | ||
| (2). Lefebvre et al., J. Virol., 2011 Transcriptome analysis of T-cell line (Sup T1) |
|||||
| Log2 Fold Change | unknown | ||||
| (3). Li et al., J. Immunol., 2013 Lymphatic tissue |
|||||
| Acute Fold Change | Acute P Value | Asymt Fold Change | Asypt P Value | AIDS Fold Change | AIDS P Value |
| unknown | unknown | unknown | unknown | unknown | unknown |
| (4). Chang et al., MBio., 2011 Transcriptome analysis of T-cell line (Sup T1) Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation |
|||||
| Up-regulated (True) | FALSE | ||||
| (5). Sherrill-Mix et al., BMC Retrovirol., 2015 Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based |
|||||
| Test Status | Log2 Fold Change | P Value | |||
| OK | -0.138068 | 0.582495 | |||
| (6). Rotger et al., PLoS Pathog., 2010 Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient (Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach) |
|||||
| Log2 Fold Change | P Value | ||||
| unknown | unknown | ||||
Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV
| (1). Greenwood et al., Elife, 2016 Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset |
||||||
| 6 h | 24 h | 48 h | 72 h | RTi | ||
| unknown | unknown | unknown | unknown | unknown | ||
| (2). Navare et al., Virology, 2012 SUP-T1 cell line |
||||||
| FC-4hpi | P-value | FC-8hpi | P-value | FC-20hpi | P-value | Category |
| unknown | unknown | unknown | unknown | unknown | unknown | unknown |
| (3). Hyrcza et al., J. Virolo., 2007 Primary human CD4+ and CD8+ T Cells |
||||||
| Affymetrix Prob ID | Fold Change | In CD8? | Category | |||
| unknown | unknown | unknown | unknown | |||
Protein Overview top
Drug-protein Interaction (annotations from DrugBank) top
Protein Secondary Structure (annotations from PDB) top
HIV-1 Interaction (annotations from NCBI HIV-1 Interaction Database) top
Metabolic/Signalling Pathway (annotations from KEGG database) top
| Pathway Accession Number | Description | not found |
|---|