Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002695
UniProt IDQ9NRA2
Primary gene name(s)SLC17A5
Synonym gene name(s)unknown
Protein nameSialin
Protein functionTransports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3(-/H(+ cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. {ECO:0000269|PubMed:10581036, ECO:0000269|PubMed:11751519, ECO:0000269|PubMed:15510212, ECO:0000269|PubMed:21781115, ECO:0000269|PubMed:22778404}.
Subcellular locationCell membrane {ECO:0000269|PubMed:22778404};
Multi-pass membrane protein {ECO:0000269|PubMed:22778404}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:21781115};
Multi-pass membrane protein {ECO:0000269|PubMed:21781115}. Lysosome membrane {ECO:0000269|PubMed:17897319};
Multi-pass membrane protein {ECO:0000269|PubMed:17897319}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9NRA2
Gene Ontology
(Biological Process)
Complete annatation
amino acid transport [GO:0006865];
anion transport [GO:0006820];
ion transport [GO:0006811];
sialic acid transport [GO:0015739]
Gene Ontology
(Molecular Function)
Complete annatation
sialic acid:proton symporter activity [GO:0015538];
sialic acid transmembrane transporter activity [GO:0015136];
sugar:proton symporter activity [GO:0005351]
Gene Ontology
(Cellular Component)
Complete annatation
cell junction [GO:0030054];
cytoplasm [GO:0005737];
integral component of plasma membrane [GO:0005887];
lysosomal membrane [GO:0005765];
membrane [GO:0016020];
plasma membrane [GO:0005886];
synaptic vesicle membrane [GO:0030672]
Protein-protein interaction117710
Phylogenetic treeQ9NRA2
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.396106505306690.2320680229717080.342351923654705
AZA vs. DISU0.5364886214587930.03707854442493020.445703086627491
AZA vs. IL7-0.2279155425323040.2436996583097160.994038428716508
AZA vs. SAHA0.2305640342615620.3487309804331290.719809776673831
DISU vs. CD30.9190664090250880.01481924822844170.0402496122154109
DISU vs. IL7-0.7731218278175610.002575313400923650.0497277287538062
DISU vs. SAHA-0.3044425798938760.3033558420575540.687451442937339
DMSO vs. AZA0.005773617399535860.9730541126410031
DMSO vs. CD30.3881040723335880.2300525202449660.333713699193145
DMSO vs. DISU-0.5330008466205010.03189704366842560.359795811925573
DMSO vs. IL7-0.2263366246976870.2161258634617360.724804783238115
DMSO vs. SAHA0.2189615848232330.3568474532478780.706081620683287
HIV vs. Mock in Activation0.1008347846290730.871796838258550.999983755607037
HIV vs. Mock in Latency0.1417196325864680.3993635354131190.999834320637052
IL7 vs. CD30.1754722016024480.5902358965572530.708217295717837
SAHA vs. CD30.6018491210091450.09204864833401570.162851975862129
SAHA vs. IL70.4551839072461730.06442849085152470.217269590849191
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.601919 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat upregulates 22632162

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04142 Lysosome - Homo sapiens (human)