Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002637
UniProt IDP36955
Primary gene name(s)SERPINF1
Synonym gene name(s)PEDF
Protein namePigment epithelium-derived factor
Protein functionNeurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S, stressed to R, relaxed conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}.
Subcellular locationSecreted {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P36955
Gene Ontology
(Biological Process)
Complete annatation
aging [GO:0007568];
cell proliferation [GO:0008283];
cellular response to cobalt ion [GO:0071279];
cellular response to dexamethasone stimulus [GO:0071549];
cellular response to glucose stimulus [GO:0071333];
cellular response to retinoic acid [GO:0071300];
kidney development [GO:0001822];
multicellular organism development [GO:0007275];
negative regulation of angiogenesis [GO:0016525];
negative regulation of endothelial cell migration [GO:0010596];
negative regulation of epithelial cell proliferation involved in prostate gland development [GO:0060770];
negative regulation of gene expression [GO:0010629];
negative regulation of inflammatory response [GO:0050728];
negative regulation of neuron death [GO:1901215];
ovulation cycle [GO:0042698];
positive regulation of neurogenesis [GO:0050769];
positive regulation of neuron projection development [GO:0010976];
response to acidic pH [GO:0010447];
response to arsenic-containing substance [GO:0046685];
retina development in camera-type eye [GO:0060041];
short-term memory [GO:0007614]
Gene Ontology
(Molecular Function)
Complete annatation
serine-type endopeptidase inhibitor activity [GO:0004867]
Gene Ontology
(Cellular Component)
Complete annatation
axon hillock [GO:0043203];
basement membrane [GO:0005604];
extracellular exosome [GO:0070062];
extracellular region [GO:0005576];
extracellular space [GO:0005615];
melanosome [GO:0042470];
perinuclear region of cytoplasm [GO:0048471]
Protein-protein interaction111202
Phylogenetic treeP36955
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.5960300801891780.08479024589947810.15382265120329
AZA vs. DISU0.09252732211186240.7332525343073750.974560663114398
AZA vs. IL7-0.1662868922315670.4494308638592890.999311006273513
AZA vs. SAHA0.3149903281572170.2350419682576260.606266705940358
DISU vs. CD30.6757700472495560.07433749348114450.147753609801526
DISU vs. IL7-0.2698539699177990.3176369329569640.699768286650519
DISU vs. SAHA0.2251656325290120.4617093474680520.800119649301005
DMSO vs. AZA0.1075719909336980.5848697743004041
DMSO vs. CD30.6907430238782330.04027562500768160.0801733999393133
DMSO vs. DISU0.01280114759927290.96085986493020.994280824778029
DMSO vs. IL7-0.2655151184021150.196650726659990.706981577337746
DMSO vs. SAHA0.2028625054110080.4258746964747150.763650551090275
HIV vs. Mock in Activation-0.1647545369181270.8007677338488240.999983755607037
HIV vs. Mock in Latency0.2405715141171260.185455482528310.999834320637052
IL7 vs. CD30.4354304151654970.2002786111981450.322762697165576
SAHA vs. CD30.887026285365120.01792158428140890.0419832543324781
SAHA vs. IL70.4814695340509820.06793872715188730.22500781697761
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change 1.724944909
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.829531 0.0017721
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1IMV X-ray 2.8Å A=21-418.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04310 Wnt signaling pathway - Homo sapiens (human)