Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002634
UniProt IDQ9Y6X1
Primary gene name(s)SERP1
Synonym gene name(s)RAMP4
Protein nameStress-associated endoplasmic reticulum protein 1
Protein functionInteracts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins, By similarity. {ECO:0000250}.
Subcellular locationMembrane;
Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000250};
Single-pass membrane protein {ECO:0000250};
Cytoplasmic side {ECO:0000250}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9Y6X1
Gene Ontology
(Biological Process)
Complete annatation
cellular protein modification process [GO:0006464];
endoplasmic reticulum unfolded protein response [GO:0030968];
glucose metabolic process [GO:0006006];
IRE1-mediated unfolded protein response [GO:0036498];
multicellular organism aging [GO:0010259];
muscle organ morphogenesis [GO:0048644];
plasma membrane organization [GO:0007009];
positive regulation of growth hormone secretion [GO:0060124];
positive regulation of insulin secretion [GO:0032024];
positive regulation of organ growth [GO:0046622];
positive regulation of translation [GO:0045727];
post-embryonic development [GO:0009791];
protein glycosylation [GO:0006486];
protein transport [GO:0015031];
response to stress [GO:0006950];
skeletal system development [GO:0001501]
Gene Ontology
(Molecular Function)
Complete annatation
unknown
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasmic microtubule [GO:0005881];
cytosol [GO:0005829];
endoplasmic reticulum [GO:0005783];
endoplasmic reticulum membrane [GO:0005789];
integral component of membrane [GO:0016021];
ribosome [GO:0005840]
Protein-protein interaction118079
Phylogenetic treeQ9Y6X1
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.1926176880376370.5557534034114420.666479574810412
AZA vs. DISU-0.1940630097504530.4436946477010930.91814655876178
AZA vs. IL7-0.02855434689232030.8816247176707660.999311006273513
AZA vs. SAHA0.05820134853517860.8111202784358710.952541841472602
DISU vs. CD3-0.3982318720437280.2730130965837190.401905338649719
DISU vs. IL70.1566118141272630.5350283199806450.846244037740869
DISU vs. SAHA0.2529015524072220.3877782879597370.753702163765953
DMSO vs. AZA-0.1556969390203140.3513240574764431
DMSO vs. CD3-0.3588311660762360.2614988111341010.368592479162729
DMSO vs. DISU0.03668768899627510.8806198271803240.987443803738299
DMSO vs. IL70.134379938812550.4537814234091920.870758796926069
DMSO vs. SAHA0.2065521057632080.3804057511277790.728012073047208
HIV vs. Mock in Activation-0.1776195634961060.7750445552960640.999983755607037
HIV vs. Mock in Latency-0.04073500091899910.8043229477093560.999834320637052
IL7 vs. CD3-0.2125738740469130.5075285661775350.63625297945323
SAHA vs. CD3-0.1591826840639240.6520181888522080.740739849679817
SAHA vs. IL70.08294259358736910.7329621299000110.878412398323483
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.3626 0.02556

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.201366 0.279714
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
200970_s_at 1.37 No downregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat modulates 21956116
24489003
Vpr downregulates 21816823
24489003

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found
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