Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002619
UniProt IDO75326
Primary gene name(s)SEMA7A
Synonym gene name(s)CD108, SEMAL
Protein nameSemaphorin-7A
Protein functionPlays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:17377534, ECO:0000269|PubMed:17671519}.
Subcellular locationCell membrane {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866};
Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866};
Extracellular side {ECO:0000269|PubMed:10201933, ECO:0000269|PubMed:17671519, ECO:0000269|PubMed:9712866}. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O75326
Gene Ontology
(Biological Process)
Complete annatation
axon extension [GO:0048675];
immune response [GO:0006955];
inflammatory response [GO:0006954];
integrin-mediated signaling pathway [GO:0007229];
neural crest cell migration [GO:0001755];
olfactory lobe development [GO:0021988];
osteoblast differentiation [GO:0001649];
positive regulation of axon extension [GO:0045773];
positive regulation of cell migration [GO:0030335];
positive regulation of ERK1 and ERK2 cascade [GO:0070374];
positive regulation of macrophage cytokine production [GO:0060907];
regulation of inflammatory response [GO:0050727]
Gene Ontology
(Molecular Function)
Complete annatation
integrin binding [GO:0005178];
neuropilin binding [GO:0038191]
Gene Ontology
(Cellular Component)
Complete annatation
anchored component of membrane [GO:0031225];
external side of plasma membrane [GO:0009897];
membrane [GO:0016020];
plasma membrane [GO:0005886]
Protein-protein interaction114056
Phylogenetic treeO75326
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD34.7327769501609500
AZA vs. DISU-0.07764426990171410.8684199937757430.991211477030548
AZA vs. IL7-0.005411118228582160.9886138909426080.999311006273513
AZA vs. SAHA-0.1090057415742980.7952187798789390.946028560326346
DISU vs. CD3-4.8241166006411800
DISU vs. IL70.06272885736358650.8924888894895310.98029047000329
DISU vs. SAHA-0.02959069021561280.9523505375928540.989441867353937
DMSO vs. AZA0.09951748480711530.8042277068042741
DMSO vs. CD3-4.6489967286910700
DMSO vs. DISU0.1742138090969870.7159536430990570.962911325435322
DMSO vs. IL7-0.09685197951745840.8056649392337880.96127184513863
DMSO vs. SAHA-0.2132958527578950.6205533325891080.87560708505294
HIV vs. Mock in Activation-0.1770719666675250.7763256892533970.999983755607037
HIV vs. Mock in Latency-0.01598302507599680.9319416473896940.999834320637052
IL7 vs. CD3-4.7338990327896700
SAHA vs. CD3-4.8661761588337900
SAHA vs. IL7-0.1060874544885440.7984094205693770.91246446342831
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.621551975
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 1.1922 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.886 0.434 0.547 0.687 0.529
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3NVQ X-ray 2.4Å A/E=45-634.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef downregulates 25275127
Vpu downregulates 25275127

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04360 Axon guidance - Homo sapiens (human)