Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002618
UniProt IDQ9H3T2
Primary gene name(s)SEMA6C
Synonym gene name(s)KIAA1869, SEMAY
Protein nameSemaphorin-6C
Protein functionShows growth cone collapsing activity on dorsal root ganglion, DRG neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. {ECO:0000269|PubMed:12110693}.
Subcellular locationCell membrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9H3T2
Gene Ontology
(Biological Process)
Complete annatation
axon guidance [GO:0007411];
negative regulation of axon extension involved in axon guidance [GO:0048843];
neural crest cell migration [GO:0001755];
positive regulation of cell migration [GO:0030335];
semaphorin-plexin signaling pathway [GO:0071526]
Gene Ontology
(Molecular Function)
Complete annatation
chemorepellent activity [GO:0045499];
semaphorin receptor binding [GO:0030215]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of plasma membrane [GO:0005887]
Protein-protein interactionunknown
Phylogenetic treeQ9H3T2
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.078024501888430.002127580716742020.00697561378349699
AZA vs. DISU0.7297113977469320.007764113860681770.221590064552732
AZA vs. IL7-0.609698714158240.009391716734166610.311809132894479
AZA vs. SAHA1.08957894442934.58164711744091e-050.00211204124306741
DISU vs. CD32.795796195914474.81189879093513e-050.00029898830327517
DISU vs. IL7-1.351566136768571.18277295124702e-060.00014735786975247
DISU vs. SAHA0.3635132560947630.2333375434556660.610526367494735
DMSO vs. AZA0.1303932978560970.5273280764624781
DMSO vs. CD32.195238309481270.001136598706287570.00383920616821127
DMSO vs. DISU-0.60223837767290.02183538051406140.305511282278984
DMSO vs. IL7-0.7318520709871230.0008539634149590250.0506573826877345
DMSO vs. SAHA0.955551299606330.0001918577530762850.00565848962155127
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.0460879432881340.8592457683947160.999834320637052
IL7 vs. CD31.472890811945120.03192682130433870.0765319620738385
SAHA vs. CD33.14220595463333.26183818791792e-050.000178748732697902
SAHA vs. IL71.700626267205521.48919840903261e-081.29758247501489e-06
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
0.3584 0.0424

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.220548 0.470755
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04360 Axon guidance - Homo sapiens (human)