Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002615
UniProt IDQ14242
Primary gene name(s)SELPLG
Synonym gene name(s)unknown
Protein nameP-selectin glycoprotein ligand 1
Protein functionA SLe(x-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. {ECO:0000269|PubMed:11566773, ECO:0000269|PubMed:12403782}.; FUNCTION:, Microbial infection Acts as a receptor for enterovirus 71. {ECO:0000269|PubMed:19543284}.
Subcellular locationMembrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q14242
Gene Ontology
(Biological Process)
Complete annatation
cell adhesion [GO:0007155];
cellular response to interleukin-6 [GO:0071354];
leukocyte adhesive activation [GO:0050902];
leukocyte migration [GO:0050900]
Gene Ontology
(Molecular Function)
Complete annatation
receptor binding [GO:0005102];
virus receptor activity [GO:0001618]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of membrane [GO:0016021];
integral component of plasma membrane [GO:0005887];
membrane [GO:0016020];
plasma membrane [GO:0005886];
uropod [GO:0001931]
Protein-protein interaction112304
Phylogenetic treeQ14242
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-3.9677586566538900
AZA vs. DISU0.02282768424818630.9345338838396710.995042856396371
AZA vs. IL70.027679055819620.8851691222389830.999311006273513
AZA vs. SAHA-0.6619317308344480.01566843883900090.130706168820753
DISU vs. CD33.978984816051821.11022302462516e-167.37246778555049e-15
DISU vs. IL7-0.004924001635930140.9846424697390140.997754944136459
DISU vs. SAHA-0.6815909339712160.03869020786454620.241149761259957
DMSO vs. AZA0.06224188469505430.7089739869682461
DMSO vs. CD34.018246827806800
DMSO vs. DISU0.03741967069123760.8780523565437990.987443803738299
DMSO vs. IL7-0.0271794150407530.8793747437408390.97351733065793
DMSO vs. SAHA-0.7286074971541190.002195933704331130.0311870655304489
HIV vs. Mock in Activation-0.1530798963056940.8507302557778670.999983755607037
HIV vs. Mock in Latency0.2935640804046910.0743223735066730.999834320637052
IL7 vs. CD34.000999279879300
SAHA vs. CD33.284458291883552.13384865332955e-137.25893887261317e-12
SAHA vs. IL7-0.6912890257731320.005369952645247310.0406291077338592
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.512957 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1G1S X-ray 1.9Å C/D=42-60.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Pr55(Gag) co-localizes with 21060818
22830021
23536680
Pr55(Gag) associates with 23536680
2532032923536680
2532032925320329
Vpu downregulates 25275127

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa05150 Staphylococcus aureus infection - Homo sapiens (human)
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