Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002610
UniProt IDP61619
Primary gene name(s)SEC61A1
Synonym gene name(s)SEC61A
Protein nameProtein transport protein Sec61 subunit alpha isoform 1
Protein functionPlays a crucial role in the insertion of secretory and membrane polypeptides into the ER. Required for assembly of membrane and secretory proteins. Tightly associated with membrane-bound ribosomes, either directly or through adapter proteins. Plays a role in pronephric kidney tubule development, By similarity. {ECO:0000250|UniProtKB:P61620}.
Subcellular locationEndoplasmic reticulum membrane {ECO:0000269|PubMed:27392076};
Multi-pass membrane protein {ECO:0000305}. Note=Localizes exclusively in granular structures in the endoplasmic reticulum, ER. {ECO:0000269|PubMed:27392076}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P61619
Gene Ontology
(Biological Process)
Complete annatation
cell growth [GO:0016049];
endoplasmic reticulum organization [GO:0007029];
IRE1-mediated unfolded protein response [GO:0036498];
posttranslational protein targeting to membrane [GO:0006620];
protein targeting to ER [GO:0045047];
response to interferon-gamma [GO:0034341];
SRP-dependent cotranslational protein targeting to membrane [GO:0006614]
Gene Ontology
(Molecular Function)
Complete annatation
ribosome binding [GO:0043022]
Gene Ontology
(Cellular Component)
Complete annatation
cytosol [GO:0005829];
integral component of endoplasmic reticulum membrane [GO:0030176];
membrane [GO:0016020];
rough endoplasmic reticulum [GO:0005791]
Protein-protein interaction118968
Phylogenetic treeP61619
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.1519806230841090.64235845813880.73978961420249
AZA vs. DISU0.0588544565635050.8159944502914560.984256604838454
AZA vs. IL7-0.02634910187508810.8906249797981610.999311006273513
AZA vs. SAHA-0.5265787503768190.0314281335078790.204987378376813
DISU vs. CD3-0.1052640363833360.7728402778842580.842966305993292
DISU vs. IL7-0.09433907388610720.7086410263881670.924840143472477
DISU vs. SAHA-0.583493174467670.04548342888724170.265042675047429
DMSO vs. AZA0.03510034892320070.833281525772811
DMSO vs. CD3-0.1305211632167410.6831089403357730.766728966335748
DMSO vs. DISU-0.02615497780956790.9145787345292280.988283279918411
DMSO vs. IL7-0.05381743322237310.7639605756050940.951841190064606
DMSO vs. SAHA-0.5669399539664210.01650719214613440.124764239134599
HIV vs. Mock in Activation0.02124280952361710.9727177786871410.999983755607037
HIV vs. Mock in Latency0.03916409573613420.8115741789728650.999834320637052
IL7 vs. CD3-0.1713761915746180.5931784735628360.710463707493532
SAHA vs. CD3-0.7020167735818720.04946540892283210.0980588940367114
SAHA vs. IL7-0.5030243902723590.03984120682010340.157257489292024
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.159509 0.329576
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.082 0.932 0.981 1.029 0.912
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Envelope surface glycoprotein gp120 complexes with 23125841
Gag-Pol complexes with 23125841
Envelope surface glycoprotein gp160; precursor interacts with 22190034
Envelope surface glycoprotein gp120 interacts with 22190034
Pr55(Gag) complexes with 23125841
Nef complexes with 23125841

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03060 Protein export - Homo sapiens (human)
hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
hsa04145 Phagosome - Homo sapiens (human)
hsa05110 Vibrio cholerae infection - Homo sapiens (human)
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