Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002606
UniProt IDO76054
Primary gene name(s)SEC14L2
Synonym gene name(s)C22orf6, KIAA1186, KIAA1658
Protein nameSEC14-like protein 2
Protein functionCarrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell.
Subcellular locationCytoplasm. Nucleus. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O76054
Gene Ontology
(Biological Process)
Complete annatation
positive regulation of transcription, DNA-templated [GO:0045893];
regulation of cholesterol biosynthetic process [GO:0045540];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
phospholipid binding [GO:0005543];
transporter activity [GO:0005215];
vitamin E binding [GO:0008431]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
extracellular exosome [GO:0070062];
integral component of membrane [GO:0016021];
nucleus [GO:0005634]
Protein-protein interaction117085
Phylogenetic treeO76054
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.715278815196275.21203436520956e-074.31388149107296e-06
AZA vs. DISU-0.2718320541342590.2997110730748860.86128089010194
AZA vs. IL7-0.01551590815616760.9387472817665410.999311006273513
AZA vs. SAHA0.4877755403546360.05310831436231410.280306278255435
DISU vs. CD3-1.999761461595941.20184186158667e-071.45514572060703e-06
DISU vs. IL70.2453898259929120.3455798684047190.726686639168802
DISU vs. SAHA0.7623165779281930.01051229582648820.106903380837384
DMSO vs. AZA0.02645013322509680.8824171797818531
DMSO vs. CD3-1.700694751011193.45543880619914e-072.69860993340539e-06
DMSO vs. DISU0.2959566914031290.241689888382320.759425522326595
DMSO vs. IL7-0.03448810934813970.8552537524175070.968156458171821
DMSO vs. SAHA0.4561315975643380.06095474810382150.283521416156346
HIV vs. Mock in Activation-0.1679209226903370.7878251111083990.999983755607037
HIV vs. Mock in Latency-0.04440252091389750.8137194410608740.999834320637052
IL7 vs. CD3-1.726029017791562.57425489813556e-072.87207580159862e-06
SAHA vs. CD3-1.251419736010610.0005148454401014970.0020069117388333
SAHA vs. IL70.5014915660193050.04575927812178230.173266857173511
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.00288582 0.989598
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.049 0.939 1.053 1.03 0.997
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00163 Vitamin E approved, nutraceutical, vet_approved unknown unknown
DB03796 Palmitic Acid experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1O6U X-ray 2.0Å A/C/E=1-403.
1OLM X-ray 1.9Å A/C/E=1-403.
4OMJ X-ray 1.6Å A/B=1-275.
4OMK X-ray 1.7Å A/B=1-275.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found