Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002604
UniProt IDP21912
Primary gene name(s)SDHB
Synonym gene name(s)SDH, SDH1
Protein nameSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
Protein functionIron-sulfur protein, IP subunit of succinate dehydrogenase, SDH that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone, coenzyme Q.
Subcellular locationMitochondrion inner membrane;
Peripheral membrane protein;
Matrix side.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P21912
Gene Ontology
(Biological Process)
Complete annatation
aerobic respiration [GO:0009060];
respiratory electron transport chain [GO:0022904];
succinate metabolic process [GO:0006105];
tricarboxylic acid cycle [GO:0006099]
Gene Ontology
(Molecular Function)
Complete annatation
2 iron, 2 sulfur cluster binding [GO:0051537];
3 iron, 4 sulfur cluster binding [GO:0051538];
4 iron, 4 sulfur cluster binding [GO:0051539];
electron carrier activity [GO:0009055];
metal ion binding [GO:0046872];
succinate dehydrogenase, ubiquinone activity [GO:0008177];
ubiquinone binding [GO:0048039]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
mitochondrial inner membrane [GO:0005743];
mitochondrial respiratory chain complex II, succinate dehydrogenase complex, ubiquinone [GO:0005749];
mitochondrion [GO:0005739];
nucleoplasm [GO:0005654];
plasma membrane [GO:0005886]
Protein-protein interaction112291
Phylogenetic treeP21912
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.144365513229250.0005655152978591980.00221273275424035
AZA vs. DISU0.1058685716866460.6764360822640610.964490872497963
AZA vs. IL70.1783035204347760.3562579057552290.999311006273513
AZA vs. SAHA-0.2370574914842510.3331898719123160.705407883315485
DISU vs. CD3-1.050573678035780.004105259919888970.0137670051240059
DISU vs. IL70.06335387636393240.8017945395971540.956254168071764
DISU vs. SAHA-0.3414807771949930.2427804516691860.621952097077393
DMSO vs. AZA-0.08740900235967920.6048886110310471
DMSO vs. CD3-1.243858855655290.0001279124199254910.000560403328034317
DMSO vs. DISU-0.1952609636849890.4249302219323810.880629497839006
DMSO vs. IL70.2731259040626110.1311154967173450.628942150153479
DMSO vs. SAHA-0.1557478245990990.5104862013725550.819769583472113
HIV vs. Mock in Activation-0.07732844707125040.9010720446233220.999983755607037
HIV vs. Mock in Latency-0.02881021701940880.8625660185622770.999834320637052
IL7 vs. CD3-0.9586643639719320.003099600291547660.0111958483571766
SAHA vs. CD3-1.4058467578059.56508300029579e-050.000464088218977648
SAHA vs. IL7-0.4184797075752380.08719118856456150.264397500789016
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
1.7 0.000568162 1.2 0.037773869 1.4 0.006076131
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.142944 0.416747
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.019 0.944 1.027 0.983 0.83
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB00139 Succinic acid approved, nutraceutical unknown unknown
DB04141 2-Hexyloxy-6-Hydroxymethyl-Tetrahydro-Pyran-3,4,5-Triol experimental unknown unknown
DB08689 UBIQUINONE-1 experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat binds 7778269
Tat downregulates 23025307

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00020 Citrate cycle (TCA cycle) - Homo sapiens (human)
hsa00190 Oxidative phosphorylation - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)
hsa01200 Carbon metabolism - Homo sapiens (human)
hsa04932 Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human)
hsa05010 Alzheimer's disease - Homo sapiens (human)
hsa05012 Parkinson's disease - Homo sapiens (human)
hsa05016 Huntington's disease - Homo sapiens (human)