Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002578
UniProt IDO95136
Primary gene name(s)S1PR2
Synonym gene name(s)EDG5
Protein nameSphingosine 1-phosphate receptor 2
Protein functionReceptor for the lysosphingolipid sphingosine 1-phosphate, S1P. S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.
Subcellular locationCell membrane;
Multi-pass membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O95136
Gene Ontology
(Biological Process)
Complete annatation
actin cytoskeleton reorganization [GO:0031532];
activation of MAPK activity [GO:0000187];
filopodium assembly [GO:0046847];
G-protein coupled receptor signaling pathway [GO:0007186];
negative regulation of excitatory postsynaptic potential [GO:0090394];
positive regulation of cell proliferation [GO:0008284];
positive regulation of establishment of endothelial barrier [GO:1903142];
positive regulation of peptidyl-threonine phosphorylation [GO:0010800];
sphingosine-1-phosphate signaling pathway [GO:0003376]
Gene Ontology
(Molecular Function)
Complete annatation
G-protein coupled receptor activity [GO:0004930];
G-protein coupled receptor binding [GO:0001664];
integrin binding [GO:0005178];
lipid binding [GO:0008289];
sphingosine-1-phosphate receptor activity [GO:0038036]
Gene Ontology
(Cellular Component)
Complete annatation
integral component of membrane [GO:0016021];
plasma membrane [GO:0005886]
Protein-protein interaction114708
Phylogenetic treeO95136
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.439863409942550.0001039880559255970.000499142668442865
AZA vs. DISU0.008431036366268870.9743737188971460.997811953897277
AZA vs. IL7-0.1060475733238260.607180597355290.999311006273513
AZA vs. SAHA-0.1789422420129550.483899540842680.811065327688238
DISU vs. CD3-1.444041600786550.0001541790822032760.000827669332312032
DISU vs. IL7-0.1238111898807740.635349589190410.891962661300561
DISU vs. SAHA-0.1860161324078540.5351788167500350.843692118932689
DMSO vs. AZA-0.01483873531499550.9355238884463441
DMSO vs. CD3-1.466914711663359.84561564111308e-050.000443951510426126
DMSO vs. DISU-0.02576351429616990.9189256973336240.988899823982894
DMSO vs. IL7-0.08299949609266620.6680263422624890.931620201164749
DMSO vs. SAHA-0.1700729098524850.4904121571010680.808210107630622
HIV vs. Mock in Activation0.3360705261036670.6608081559704610.999983755607037
HIV vs. Mock in Latency-0.07228095640904060.685447767532840.999834320637052
IL7 vs. CD3-1.54047898421292.41403647615046e-050.000168379323484571
SAHA vs. CD3-1.643519894175793.58489578962118e-050.000194192593636201
SAHA vs. IL7-0.07558263097304670.7667687209917930.896560903716785
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.146412 0.377856
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1ZTI Model - A=1-353.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04071 Sphingolipid signaling pathway - Homo sapiens (human)
hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)