Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002557
UniProt IDQ9HB90
Primary gene name(s)RRAGC
Synonym gene name(s)unknown
Protein nameRas-related GTP-binding protein C
Protein functionGuanine nucleotide-binding protein forming heterodimeric Rag complexes required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. {ECO:0000269|PubMed:20381137, ECO:0000269|PubMed:27234373}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:11073942}. Nucleus {ECO:0000269|PubMed:11073942}. Lysosome {ECO:0000269|PubMed:20381137}. Note=Predominantly cytoplasmic. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA, PubMed:11073942. {ECO:0000269|PubMed:11073942}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q9HB90
Gene Ontology
(Biological Process)
Complete annatation
apoptotic process [GO:0006915];
cell cycle arrest [GO:0007050];
cell growth [GO:0016049];
cellular protein localization [GO:0034613];
cellular response to amino acid starvation [GO:0034198];
cellular response to amino acid stimulus [GO:0071230];
macroautophagy [GO:0016236];
positive regulation of TOR signaling [GO:0032008];
regulation of autophagy [GO:0010506];
regulation of TORC1 signaling [GO:1903432];
regulation of TOR signaling [GO:0032006];
response to amino acid [GO:0043200];
RNA splicing [GO:0008380];
small GTPase mediated signal transduction [GO:0007264];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
GDP binding [GO:0019003];
GTPase activity [GO:0003924];
GTP binding [GO:0005525];
magnesium ion binding [GO:0000287];
protein heterodimerization activity [GO:0046982]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
EGO complex [GO:0034448];
Gtr1-Gtr2 GTPase complex [GO:1990131];
intracellular membrane-bounded organelle [GO:0043231];
lysosome [GO:0005764];
nucleus [GO:0005634]
Protein-protein interaction122074
Phylogenetic treeQ9HB90
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
      unknown
Brass et al., Science, 2008
      unknown
Smith et al., J. Immunol, 2010
      unknown
Interferon-stimulated
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model


DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.056781721470250.001613440543595690.00551298478192569
AZA vs. DISU0.7182235707882990.004931785285013920.181764624416381
AZA vs. IL7-0.1976381310494110.3087278500622070.999311006273513
AZA vs. SAHA0.1708967256716630.4860949787371350.811989772770786
DISU vs. CD31.761553476491292.49489395165448e-062.16511407180424e-05
DISU vs. IL7-0.9243897291253010.0002912866850461880.0117527554542074
DISU vs. SAHA-0.5459564490613770.06373945236168220.319141955662097
DMSO vs. AZA-0.04820004528843990.7762435921508171
DMSO vs. CD30.9960764064198850.002307195967109040.00705887636971928
DMSO vs. DISU-0.7685946000173030.001827377648325860.0881592834899272
DMSO vs. IL7-0.1421215040462440.4340704833738570.860024653866327
DMSO vs. SAHA0.2124343684063510.3703043460405180.717909100209254
HIV vs. Mock in Activation-0.302377917466550.6286648607718120.999983755607037
HIV vs. Mock in Latency0.06376846020685750.7028190758629920.999834320637052
IL7 vs. CD30.8681184257587170.007998934321116310.0247962310939148
SAHA vs. CD31.202290847610650.0009796109050030920.00351996574592194
SAHA vs. IL70.3646100330648240.1372069060417880.347781554006038
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.145027 0.327481
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.048 1.016 1.077 1.141 1.228
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3LLU X-ray 1.4Å A=60-237.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04150 mTOR signaling pathway - Homo sapiens (human)
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