Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002467
UniProt IDP35241
Primary gene name(s)RDX
Synonym gene name(s)unknown
Protein nameRadixin
Protein functionProbably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
Subcellular locationCell membrane;
Peripheral membrane protein;
Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Note=Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P35241
Gene Ontology
(Biological Process)
Complete annatation
apical protein localization [GO:0045176];
barbed-end actin filament capping [GO:0051016];
cellular response to platelet-derived growth factor stimulus [GO:0036120];
cellular response to thyroid hormone stimulus [GO:0097067];
establishment of endothelial barrier [GO:0061028];
establishment of protein localization [GO:0045184];
establishment of protein localization to plasma membrane [GO:0090002];
microvillus assembly [GO:0030033];
negative regulation of adherens junction organization [GO:1903392];
negative regulation of cell size [GO:0045792];
negative regulation of GTPase activity [GO:0034260];
negative regulation of homotypic cell-cell adhesion [GO:0034111];
positive regulation of cell migration [GO:0030335];
positive regulation of cellular protein catabolic process [GO:1903364];
positive regulation of early endosome to late endosome transport [GO:2000643];
positive regulation of G1/S transition of mitotic cell cycle [GO:1900087];
positive regulation of gene expression [GO:0010628];
positive regulation of protein localization to early endosome [GO:1902966];
protein kinase A signaling [GO:0010737];
regulation of actin filament bundle assembly [GO:0032231];
regulation of cell shape [GO:0008360];
regulation of cell size [GO:0008361];
regulation of GTPase activity [GO:0043087];
regulation of organelle assembly [GO:1902115];
regulation of Rap protein signal transduction [GO:0032487];
regulation of ruffle assembly [GO:1900027]
Gene Ontology
(Molecular Function)
Complete annatation
actin binding [GO:0003779];
ATPase binding [GO:0051117];
poly(A RNA binding [GO:0044822];
protein homodimerization activity [GO:0042803];
protein kinase A binding [GO:0051018]
Gene Ontology
(Cellular Component)
Complete annatation
apical plasma membrane [GO:0016324];
cell periphery [GO:0071944];
cleavage furrow [GO:0032154];
cortical actin cytoskeleton [GO:0030864];
extracellular exosome [GO:0070062];
extracellular space [GO:0005615];
extrinsic component of membrane [GO:0019898];
filopodium [GO:0030175];
focal adhesion [GO:0005925];
lamellipodium [GO:0030027];
microvillus [GO:0005902];
myelin sheath [GO:0043209];
plasma membrane [GO:0005886];
ruffle [GO:0001726];
stereocilium [GO:0032420]
Protein-protein interaction111894
Phylogenetic treeP35241
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.132156517265280.0006702554502941990.00255749117641371
AZA vs. DISU-0.1142580672410570.6530008714732720.960057478314726
AZA vs. IL70.029478989269460.8792032930775510.999311006273513
AZA vs. SAHA0.4634680435443910.06021101334188530.300835536995551
DISU vs. CD3-1.258653195202130.0006633255975883050.00290161638364658
DISU vs. IL70.1350824103740560.5934044198041310.874255623566575
DISU vs. SAHA0.5780229929265030.04982541274303150.279096953725224
DMSO vs. AZA-0.1197936383862560.4805227982604441
DMSO vs. CD3-1.264237833028040.0001030813808595710.000463005665667691
DMSO vs. DISU-0.007780762889707210.974690760866920.995550083527576
DMSO vs. IL70.1566656330191130.3883832405405620.839072705842765
DMSO vs. SAHA0.5758159916330860.0156533634916270.120468864067612
HIV vs. Mock in Activation-0.09524522403564720.8792701203353880.999983755607037
HIV vs. Mock in Latency-0.09938073945460810.5815540219999730.999834320637052
IL7 vs. CD3-1.09363887712510.0008029544155889750.00351829415877111
SAHA vs. CD3-0.6947704117919370.05022902113476670.0992723080001225
SAHA vs. IL70.4297367086008170.08065053564189620.252225347358079
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock 0.77 4.54E-06 9.39E-05
Infected vs. Bystander 0.918 3.06E-07 6.59E-06
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
-1.4 0.026366271 -1.5 0.009127879 -1.7 0.012678569
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.47321 0.000305467
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.05 1.031 1.208 1.384 1.13
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB03401 D-Myo-Inositol-1,4,5-Triphosphate experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr downregulates 17349711
Pr55(Gag) co-localizes with 24760896
Envelope surface glycoprotein gp120 relocalizes 15818415

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04530 Tight junction - Homo sapiens (human)
hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05206 MicroRNAs in cancer - Homo sapiens (human)