Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002449
UniProt IDQ16576
Primary gene name(s)RBBP7
Synonym gene name(s)RBAP46
Protein nameHistone-binding protein RBBP7
Protein functionCore histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase, HAT complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase, HDAC complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex, the NuRD complex, which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF, nucleosome remodeling factor complex. {ECO:0000269|PubMed:10866654}.
Subcellular locationNucleus.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q16576
Gene Ontology
(Biological Process)
Complete annatation
cell proliferation [GO:0008283];
cellular heat acclimation [GO:0070370];
CENP-A containing nucleosome assembly [GO:0034080];
DNA replication [GO:0006260];
multicellular organism development [GO:0007275];
negative regulation of cell growth [GO:0030308];
negative regulation of gene expression, epigenetic [GO:0045814];
negative regulation of transcription from RNA polymerase II promoter [GO:0000122];
regulation of signal transduction by p53 class mediator [GO:1901796];
response to steroid hormone [GO:0048545];
transcription, DNA-templated [GO:0006351]
Gene Ontology
(Molecular Function)
Complete annatation
histone deacetylase activity [GO:0004407];
RNA binding [GO:0003723]
Gene Ontology
(Cellular Component)
Complete annatation
ESC/E(Z complex [GO:0035098];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
NuRD complex [GO:0016581]
Protein-protein interaction111866
Phylogenetic treeQ16576
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.9611200749931140.003746165456574020.0113742122577074
AZA vs. DISU-0.1736947609732160.4923893001224780.932798329778338
AZA vs. IL70.2001476084413650.2983918163415080.999311006273513
AZA vs. SAHA0.1963091352907680.4219449342591520.775280099832088
DISU vs. CD3-1.147416470020780.00181772445176720.00690707798990138
DISU vs. IL70.3647872287397170.1480311805675630.500724412892221
DISU vs. SAHA0.3713951613765990.203880836004090.577648053829687
DMSO vs. AZA-0.02968614343922840.8595684266195081
DMSO vs. CD3-1.002925687456350.002001664269965060.00624328617536722
DMSO vs. DISU0.1419546640288530.5608643266127380.925732173460781
DMSO vs. IL70.2371095886390930.1881360498864690.699156568926471
DMSO vs. SAHA0.219538355760180.3523160448611290.702333306721896
HIV vs. Mock in Activation-0.07164465335770670.9082122192273040.999983755607037
HIV vs. Mock in Latency-0.05236984326523140.7512544287131890.999834320637052
IL7 vs. CD3-0.7531001401001570.01983643538246620.0520533757868928
SAHA vs. CD3-0.7896218547312630.02808614755203990.0612796067191604
SAHA vs. IL7-0.00709701064885910.9768363215143110.991637868577462
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.290382 0.0275573
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.003 0.992 0.898 0.939 0.904
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
3CFS X-ray 2.4Å B=1-411.
3CFV X-ray 2.6Å A/B=1-411.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpr interacts with 22190034
Vpr complexes with 24116224
Tat interacts with 19454010

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found