Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002437
UniProt IDP46060
Primary gene name(s)RANGAP1
Synonym gene name(s)KIAA1835, SD
Protein nameRan GTPase-activating protein 1
Protein functionGTPase activator for the nuclear Ras-related regulatory protein Ran, converting it to the putatively inactive GDP-bound state.
Subcellular locationCytoplasm. Nucleus membrane;
Peripheral membrane protein;
Cytoplasmic side. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Cytoplasmic during interphase. Targeted to the nuclear rim after sumoylation. During mitosis, associates with mitotic spindles. Association with kinetochores appears soon after nuclear envelope breakdown and persists until late anaphase. Mitotic location also requires sumoylation.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P46060
Gene Ontology
(Biological Process)
Complete annatation
cellular response to vasopressin [GO:1904117];
negative regulation of protein export from nucleus [GO:0046826];
protein sumoylation [GO:0016925];
response to axon injury [GO:0048678];
signal transduction [GO:0007165];
sister chromatid cohesion [GO:0007062]
Gene Ontology
(Molecular Function)
Complete annatation
GTPase activator activity [GO:0005096]
Gene Ontology
(Cellular Component)
Complete annatation
axon cytoplasm [GO:1904115];
condensed chromosome kinetochore [GO:0000777];
cytoplasm [GO:0005737];
cytoplasmic periphery of the nuclear pore complex [GO:1990723];
cytosol [GO:0005829];
dendrite [GO:0030425];
intracellular membrane-bounded organelle [GO:0043231];
mitotic spindle [GO:0072686];
nuclear envelope [GO:0005635];
nuclear membrane [GO:0031965];
nuclear pore [GO:0005643];
nuclear pore cytoplasmic filaments [GO:0044614];
spindle pole [GO:0000922]
Protein-protein interaction111840
Phylogenetic treeP46060
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.593406029351811.95248327261588e-061.42163419733655e-05
AZA vs. DISU0.3896834343757290.1246379982842190.686442523250392
AZA vs. IL70.08283764931450210.6664210542411040.999311006273513
AZA vs. SAHA-0.1560011665734450.5224084194115990.834193274810428
DISU vs. CD3-1.216274648621080.0009709200324701240.00403853437346983
DISU vs. IL7-0.3161653760107370.2104577517962960.59048029189078
DISU vs. SAHA-0.5434872000875890.06309114535433060.317902591653332
DMSO vs. AZA0.08115646643748560.6281338047568541
DMSO vs. CD3-1.524804377624713.04589063182537e-061.97106281651414e-05
DMSO vs. DISU-0.3107865154360870.2031511011428620.717984778194872
DMSO vs. IL70.009372847751675570.9584095431856080.992579572389115
DMSO vs. SAHA-0.242614574295530.3033961879369360.655769489080648
HIV vs. Mock in Activation0.1743461358553040.7796279953654780.999983755607037
HIV vs. Mock in Latency-0.09564154906884320.5628729151309240.999834320637052
IL7 vs. CD3-1.504315976909274.44590066461803e-063.72501727169469e-05
SAHA vs. CD3-1.773041551611181.06365379226592e-068.56264030419197e-06
SAHA vs. IL7-0.2418538125605130.3205436038277320.570065394537427
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.278534 0.0350181
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.983 0.991 0.619 0.543 1.071
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1Z5S X-ray 3.0Å C=418-587.
2GRN X-ray 1.8Å B=419-587.
2GRO X-ray 1.7Å B=419-587.
2GRP X-ray 2.0Å B=419-587.
2GRQ X-ray 1.7Å B=419-587.
2GRR X-ray 1.3Å B=419-587.
2IO2 X-ray 2.9Å C=418-587.
2IO3 X-ray 3.2Å C=418-587.
2IY0 X-ray 2.7Å C=432-587.
3UIN X-ray 2.6Å C=419-587.
3UIO X-ray 2.6Å C=419-587.
3UIP X-ray 2.2Å C=419-587.
5D2M X-ray 2.4Å C/F=418-587.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Rev interacts with 22174317
Tat interacts with 19454010

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa03013 RNA transport - Homo sapiens (human)