Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002435
UniProt IDP43487
Primary gene name(s)RANBP1
Synonym gene name(s)unknown
Protein nameRan-specific GTPase-activating protein
Protein functionInhibits GTP exchange on Ran. Forms a Ran-GTP-RANBP1 trimeric complex. Increase GTP hydrolysis induced by the Ran GTPase activating protein RANGAP1. May act in an intracellular signaling pathway which may control the progression through the cell cycle by regulating the transport of protein and nucleic acids across the nuclear membrane.
Subcellular locationunknown
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P43487
Gene Ontology
(Biological Process)
Complete annatation
G1/S transition of mitotic cell cycle [GO:0000082];
positive regulation of mitotic centrosome separation [GO:0046604];
protein import into nucleus [GO:0006606];
RNA export from nucleus [GO:0006405];
signal transduction [GO:0007165];
spindle organization [GO:0007051];
ubiquitin-dependent protein catabolic process [GO:0006511];
viral process [GO:0016032]
Gene Ontology
(Molecular Function)
Complete annatation
GDP-dissociation inhibitor activity [GO:0005092];
GTPase activator activity [GO:0005096];
Ran GTPase binding [GO:0008536]
Gene Ontology
(Cellular Component)
Complete annatation
centrosome [GO:0005813];
cytoplasm [GO:0005737];
nuclear envelope [GO:0005635];
nucleus [GO:0005634]
Protein-protein interaction111838
Phylogenetic treeP43487
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD32.199142579232541.31759381183372e-102.23886966538419e-09
AZA vs. DISU-0.3068516368193190.2266700202493560.814255854772382
AZA vs. IL70.4306192052833550.02587547598131980.514267323998024
AZA vs. SAHA-0.1667406115745250.4961100068554610.81900802139297
DISU vs. CD3-2.518017259871095.13519227141046e-111.34388694963961e-09
DISU vs. IL70.7287075958872670.004058697761550660.0661458040598661
DISU vs. SAHA0.1414245750381210.6283186875754410.882954317881168
DMSO vs. AZA-0.1002950491714730.5523442452744991
DMSO vs. CD3-2.311626260606815.7708282596991e-121.1145836888765e-10
DMSO vs. DISU0.2045475575071850.4032478139049910.866525674539886
DMSO vs. IL70.5383943690637020.00293698495888040.104765543884407
DMSO vs. SAHA-0.07255778283069090.7591265345646210.930297284308295
HIV vs. Mock in Activation-0.2497250014456340.6879371976964570.999983755607037
HIV vs. Mock in Latency-0.1125431223639960.4996641688153030.999834320637052
IL7 vs. CD3-1.760309073697191.0195272892588e-071.23830256494746e-06
SAHA vs. CD3-2.390473017975151.47611034506667e-103.06827350346962e-09
SAHA vs. IL7-0.6001520252235370.01435592603130860.0804764704335985
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change -1.416972504
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.368502 0.00622456
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
0.071 0.008

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.965 1.045 1.064 0.951 0.967
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1K5D X-ray 2.7Å B/E/H/K=1-201.
1K5G X-ray 3.1Å B/E/H/K=1-201.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu interacts with 22190034
Rev competes with 9111043
HIV-1 virus replication enhanced by expression of human gene 18187620

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa05166 HTLV-I infection - Homo sapiens (human)
hsa05203 Viral carcinogenesis - Homo sapiens (human)