Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002418
UniProt IDQ15276
Primary gene name(s)RABEP1
Synonym gene name(s)RAB5EP, RABPT5, RABPT5A
Protein nameRab GTPase-binding effector protein 1
Protein functionRab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane, PubMed:22841712. Stimulates RABGEF1 mediated nucleotide exchange on RAB5A. {ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472}.
Subcellular locationCytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q15276
Gene Ontology
(Biological Process)
Complete annatation
apoptotic process [GO:0006915];
endocytosis [GO:0006897];
membrane fusion [GO:0061025];
protein transport [GO:0015031];
vesicle-mediated transport [GO:0016192]
Gene Ontology
(Molecular Function)
Complete annatation
GTPase activator activity [GO:0005096];
protein homodimerization activity [GO:0042803]
Gene Ontology
(Cellular Component)
Complete annatation
early endosome [GO:0005769];
endocytic vesicle [GO:0030139];
endosome [GO:0005768];
intracellular membrane-bounded organelle [GO:0043231];
recycling endosome [GO:0055037]
Protein-protein interaction114583
Phylogenetic treeQ15276
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD30.269666588308190.4103076555736680.532153599931703
AZA vs. DISU-0.03198987271284520.899444090941710.993937521279788
AZA vs. IL70.09670399089911410.6383654468525220.999311006273513
AZA vs. SAHA0.004142387252600590.9864537239305910.99724510955636
DISU vs. CD3-0.3141689135218010.3875606009286060.522127848636859
DISU vs. IL70.1201630630095470.6336204895849040.890656117706453
DISU vs. SAHA0.03624690721140630.9011536638447920.976188803154228
DMSO vs. AZA-0.1191548119141130.4776874341881171
DMSO vs. CD3-0.4006396959373630.2107880171060340.311753532073671
DMSO vs. DISU-0.0892187656025270.7148767792340260.962685308322123
DMSO vs. IL70.2231422748562230.2151907223835440.724804783238115
DMSO vs. SAHA0.1153056168044190.6248946821323050.877434686339371
HIV vs. Mock in Activation-0.2223272408670160.7212361310349980.999983755607037
HIV vs. Mock in Latency-0.127119058021070.4418124526767860.999834320637052
IL7 vs. CD3-0.1633530348155430.6110753134091790.725941193188701
SAHA vs. CD3-0.2918994797943430.4085499111641380.524343992611443
SAHA vs. IL7-0.09732330904876060.6894410616462110.854306170427866
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.104606 0.727413
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.945 0.858 0.851 0.893 0.911
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1P4U X-ray 2.2Å B=435-447.
1TU3 X-ray 2.3Å F/G/H/I/J=789-862.
1X79 X-ray 2.4Å B/C=551-661.
4N3Y X-ray 2.2Å B/C=552-642.
4N3Z X-ray 3.1Å B/C=552-642.
4Q9U X-ray 4.6Å C/D/G/H=552-642.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Nef requires 25496667

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04144 Endocytosis - Homo sapiens (human)