Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002416
UniProt IDO14966
Primary gene name(s)RAB29
Synonym gene name(s)RAB7L1
Protein nameRas-related protein Rab-7L1
Protein functionRab GTPase key regulator in vesicle trafficking. Essential for maintaining the integrity of the endosome-trans-Golgi network structure. Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor, M6PR, between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system, CNS. May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi, S.Typhi epithelial cell infection. {ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816}.
Subcellular locationCell membrane {ECO:0000305};
Lipid-anchor {ECO:0000305};
Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:24788816}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:24788816}. Golgi apparatus {ECO:0000269|PubMed:22042847}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24788816}. Vacuole {ECO:0000269|PubMed:22042847}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22042847}. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus, By similarity. Colocalizes with GM130 at the Golgi apparatus, PubMed:22042847. Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus, PubMed:22042847. Colocalizes with TGN46 at the trans-Golgi network, TGN, PubMed:24788816. In Salmonella enterica serovar Typhi, S.Typhi infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery, PubMed:22042847. {ECO:0000250|UniProtKB:Q63481, ECO:0000269|PubMed:22042847, ECO:0000269|PubMed:24788816}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: O14966
Gene Ontology
(Biological Process)
Complete annatation
Golgi organization [GO:0007030];
Golgi to endosome transport [GO:0006895];
melanosome organization [GO:0032438];
mitochondrion organization [GO:0007005];
multi-organism toxin transport [GO:1990967];
negative regulation of neuron projection development [GO:0010977];
positive regulation of intracellular protein transport [GO:0090316];
positive regulation of receptor recycling [GO:0001921];
positive regulation of T cell receptor signaling pathway [GO:0050862];
protein localization to ciliary membrane [GO:1903441];
protein localization to membrane [GO:0072657];
protein transport [GO:0015031];
regulation of neuron death [GO:1901214];
response to bacterium [GO:0009617];
retrograde transport, endosome to Golgi [GO:0042147];
retrograde transport, plasma membrane to Golgi [GO:0035526];
small GTPase mediated signal transduction [GO:0007264];
synapse assembly [GO:0007416];
T cell activation [GO:0042110];
viral RNA genome replication [GO:0039694]
Gene Ontology
(Molecular Function)
Complete annatation
Gene Ontology
(Cellular Component)
Complete annatation
Protein-protein interaction114447
Phylogenetic treeO14966
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-0.2966172308652120.366204515926020.487798008310824
AZA vs. DISU-0.09532582891174810.7063182712013550.971888783212161
AZA vs. IL70.04207197561837890.8269783202494320.999311006273513
AZA vs. SAHA-0.2937939712837170.2298869618842040.600262612756363
DISU vs. CD30.1887799257177320.603586653421240.713717070416675
DISU vs. IL70.1284024002141350.6106592082835610.880844111640685
DISU vs. SAHA-0.1969738335637250.5005245739008840.825408234299182
DMSO vs. AZA-0.02166857422911770.8972414451935851
DMSO vs. CD30.2629586031247960.4117543467662470.526085932832966
DMSO vs. DISU0.07173417211642510.768795908058130.970398466132192
DMSO vs. IL70.07098543608720870.6933336853009240.936954851917814
DMSO vs. SAHA-0.2784291981409190.2387903525020850.586738642698405
HIV vs. Mock in Activation-0.1320736264123190.8324101518144040.999983755607037
HIV vs. Mock in Latency-0.02465283801220010.8813299105894680.999834320637052
IL7 vs. CD30.3465526459564320.2811506947710480.417308399458027
SAHA vs. CD3-0.02142957932375140.9516006721609530.967979893990251
SAHA vs. IL7-0.3392324065002320.1643071741054610.386089842940877
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.2993 0.04752

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.247691 0.0659334
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.97 1.1 1.12 1.192 0.999
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
218700_s_at 1.41 No upregulated in CD8+ cells

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
not found