Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002411
UniProt IDP20336
Primary gene name(s)RAB3A
Synonym gene name(s)unknown
Protein nameRas-related protein Rab-3A
Protein functionInvolved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.
Subcellular locationCell membrane {ECO:0000305};
Lipid-anchor {ECO:0000305};
Cytoplasmic side {ECO:0000305}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P20336
Gene Ontology
(Biological Process)
Complete annatation
axonogenesis [GO:0007409];
constitutive secretory pathway [GO:0045054];
evoked neurotransmitter secretion [GO:0061670];
glutamate secretion [GO:0014047];
lung development [GO:0030324];
maintenance of presynaptic active zone structure [GO:0048790];
mitochondrion organization [GO:0007005];
neuromuscular synaptic transmission [GO:0007274];
neurotransmitter secretion [GO:0007269];
positive regulation of exocytosis [GO:0045921];
positive regulation of regulated secretory pathway [GO:1903307];
post-embryonic development [GO:0009791];
protein transport [GO:0015031];
regulation of short-term neuronal synaptic plasticity [GO:0048172];
regulation of synaptic vesicle fusion to presynaptic membrane [GO:0031630];
respiratory system process [GO:0003016];
response to electrical stimulus [GO:0051602];
sensory perception of touch [GO:0050975];
small GTPase mediated signal transduction [GO:0007264];
synaptic vesicle exocytosis [GO:0016079];
synaptic vesicle maturation [GO:0016188];
synaptic vesicle recycling [GO:0036465]
Gene Ontology
(Molecular Function)
Complete annatation
ATPase activator activity [GO:0001671];
GTPase activity [GO:0003924];
GTP binding [GO:0005525];
myosin V binding [GO:0031489]
Gene Ontology
(Cellular Component)
Complete annatation
acrosomal vesicle [GO:0001669];
axon [GO:0030424];
clathrin-sculpted acetylcholine transport vesicle membrane [GO:0060201];
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane [GO:0061202];
clathrin-sculpted glutamate transport vesicle membrane [GO:0060203];
clathrin-sculpted monoamine transport vesicle membrane [GO:0070083];
cytosol [GO:0005829];
endosome [GO:0005768];
extracellular vesicle [GO:1903561];
plasma membrane [GO:0005886];
protein complex [GO:0043234];
synaptic vesicle [GO:0008021];
terminal bouton [GO:0043195]
Protein-protein interaction111802
Phylogenetic treeP20336
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-2.218413681786320.0003738609117815980.00153831058213821
AZA vs. DISU-0.4811332438946810.1152629700624550.66735460011572
AZA vs. IL70.06552549807613710.7785512505521140.999311006273513
AZA vs. SAHA0.4690947033716430.2183036558878420.586422576835045
DISU vs. CD31.728227226157170.008362498756002920.0249351569437656
DISU vs. IL70.5348992951695080.06061423753172590.324950082073531
DISU vs. SAHA0.9543282185101670.02695700093283710.19383061119217
DMSO vs. AZA0.0009261083906243780.9965724709744431
DMSO vs. CD32.211481836481810.000337985964244170.00132047680273299
DMSO vs. DISU0.4808277818081390.09882026579031780.567971550518722
DMSO vs. IL70.07165954739946510.7436425428234530.948844914513041
DMSO vs. SAHA0.4642785301184110.2075353147724670.548442000514791
HIV vs. Mock in Activationunknownunknownunknown
HIV vs. Mock in Latency0.03478425521806720.8661676631256520.999834320637052
IL7 vs. CD32.28842834597060.0001429403505062150.000799161685155855
SAHA vs. CD32.660649039297510.0003909503893020360.00157994700101413
SAHA vs. IL70.4074056668769410.2630119646718160.508526819975306
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK -0.310357 0.367631
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
unknown unknown unknown unknown unknown
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

not found

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat upregulates 25613138

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04721 Synaptic vesicle cycle - Homo sapiens (human)
hsa04911 Insulin secretion - Homo sapiens (human)