Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002382
UniProt IDP10586
Primary gene name(s)PTPRF
Synonym gene name(s)LAR
Protein nameReceptor-type tyrosine-protein phosphatase F
Protein functionPossible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity, PTPase and dephosphorylates EPHA2 regulating its activity.; FUNCTION: The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Subcellular locationMembrane;
Single-pass type I membrane protein.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: P10586
Gene Ontology
(Biological Process)
Complete annatation
cell adhesion [GO:0007155];
cell migration [GO:0016477];
chemical synaptic transmission [GO:0007268];
negative regulation of receptor binding [GO:1900121];
neuron projection regeneration [GO:0031102];
peptidyl-tyrosine dephosphorylation [GO:0035335];
regulation of axon regeneration [GO:0048679];
transmembrane receptor protein tyrosine phosphatase signaling pathway [GO:0007185]
Gene Ontology
(Molecular Function)
Complete annatation
heparin binding [GO:0008201];
protein tyrosine phosphatase activity [GO:0004725];
transmembrane receptor protein tyrosine phosphatase activity [GO:0005001]
Gene Ontology
(Cellular Component)
Complete annatation
extracellular exosome [GO:0070062];
integral component of plasma membrane [GO:0005887];
neuronal cell body [GO:0043025];
neuron projection [GO:0043005];
plasma membrane [GO:0005886]
Protein-protein interaction111756
Phylogenetic treeP10586
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD3-1.46854630325460.05340361037764010.105408488162885
AZA vs. DISU-0.2894296673765690.7478969853489050.976008954784031
AZA vs. IL7-0.372586789599570.646482900789140.999311006273513
AZA vs. SAHA0.3838433182940160.6335829227894140.884359080062927
DISU vs. CD31.166303285014870.1612671932192460.270465250399079
DISU vs. IL7-0.09192209606954880.9141096761566130.982826001573422
DISU vs. SAHA0.6732800228309910.427963047529560.776911552450292
DMSO vs. AZA0.14592836374330.8715857660765551
DMSO vs. CD31.591808519822610.05201986741744170.099565404985867
DMSO vs. DISU0.4305027877430440.6444622011087440.947820404126923
DMSO vs. IL7-0.5096726488486720.5503294412112470.897857969069977
DMSO vs. SAHA0.2328306676061720.7826355146997530.939094778485071
HIV vs. Mock in Activation-0.5470644240951860.4062276190570420.999983755607037
HIV vs. Mock in Latency-0.122761968191980.7976735701984120.999834320637052
IL7 vs. CD31.104917034292860.09759815187042330.186261957855519
SAHA vs. CD31.824415878798240.004782199717486830.0137586387442777
SAHA vs. IL70.7507429532722110.3141669651528140.563198008001014
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) TRUE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
NOTEST -1.70003 1
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.016 0.768 0.72 0.614 0.726
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

not found

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1LAR X-ray 2.0Å A/B=1333-1907.
2DJU NMR - A=319-411.
2DN7 NMR - A=821-914.
2EDX NMR - A=596-716.
2EDY NMR - A=915-1010.
2YD5 X-ray 2.2Å A=29-231.
2YD8 X-ray 2.0Å A=29-231.
4N5U X-ray 1.4Å A=601-705.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

not found

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04514 Cell adhesion molecules (CAMs) - Homo sapiens (human)
hsa04520 Adherens junction - Homo sapiens (human)
hsa04910 Insulin signaling pathway - Homo sapiens (human)
hsa04931 Insulin resistance - Homo sapiens (human)