Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002376
UniProt IDQ06124
Primary gene name(s)PTPN11
Synonym gene name(s)PTP2C, SHPTP2
Protein nameTyrosine-protein phosphatase non-receptor type 11
Protein functionActs downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73, PubMed:26742426. {ECO:0000269|PubMed:10655584, ECO:0000269|PubMed:18559669, ECO:0000269|PubMed:18829466, ECO:0000269|PubMed:26742426}.
Subcellular locationCytoplasm {ECO:0000269|PubMed:26742426}. Nucleus {ECO:0000269|PubMed:26742426}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q06124
Gene Ontology
(Biological Process)
Complete annatation
abortive mitotic cell cycle [GO:0033277];
activation of MAPK activity [GO:0000187];
atrioventricular canal development [GO:0036302];
axonogenesis [GO:0007409];
Bergmann glial cell differentiation [GO:0060020];
brain development [GO:0007420];
cerebellar cortex formation [GO:0021697];
DNA damage checkpoint [GO:0000077];
ephrin receptor signaling pathway [GO:0048013];
epidermal growth factor receptor signaling pathway [GO:0007173];
ERBB signaling pathway [GO:0038127];
face morphogenesis [GO:0060325];
fibroblast growth factor receptor signaling pathway [GO:0008543];
genitalia development [GO:0048806];
glucose homeostasis [GO:0042593];
heart development [GO:0007507];
homeostasis of number of cells within a tissue [GO:0048873];
hormone-mediated signaling pathway [GO:0009755];
hormone metabolic process [GO:0042445];
inner ear development [GO:0048839];
integrin-mediated signaling pathway [GO:0007229];
intestinal epithelial cell migration [GO:0061582];
leukocyte migration [GO:0050900];
megakaryocyte development [GO:0035855];
microvillus organization [GO:0032528];
multicellular organismal reproductive process [GO:0048609];
multicellular organism growth [GO:0035264];
negative regulation of cell adhesion mediated by integrin [GO:0033629];
negative regulation of cortisol secretion [GO:0051463];
negative regulation of growth hormone secretion [GO:0060125];
negative regulation of insulin secretion [GO:0046676];
neurotrophin TRK receptor signaling pathway [GO:0048011];
organ growth [GO:0035265];
peptidyl-tyrosine dephosphorylation [GO:0035335];
phosphatidylinositol-mediated signaling [GO:0048015];
platelet activation [GO:0030168];
platelet-derived growth factor receptor signaling pathway [GO:0048008];
platelet formation [GO:0030220];
positive regulation of ERK1 and ERK2 cascade [GO:0070374];
positive regulation of glucose import in response to insulin stimulus [GO:2001275];
positive regulation of hormone secretion [GO:0046887];
positive regulation of mitotic cell cycle [GO:0045931];
regulation of cell adhesion mediated by integrin [GO:0033628];
regulation of multicellular organism growth [GO:0040014];
regulation of phosphatidylinositol 3-kinase signaling [GO:0014066];
regulation of protein complex assembly [GO:0043254];
regulation of protein export from nucleus [GO:0046825];
regulation of type I interferon-mediated signaling pathway [GO:0060338];
T cell costimulation [GO:0031295];
triglyceride metabolic process [GO:0006641]
Gene Ontology
(Molecular Function)
Complete annatation
1-phosphatidylinositol-3-kinase activity [GO:0016303];
insulin receptor binding [GO:0005158];
non-membrane spanning protein tyrosine phosphatase activity [GO:0004726];
phosphatidylinositol-4,5-bisphosphate 3-kinase activity [GO:0046934];
phosphoprotein phosphatase activity [GO:0004721];
protein tyrosine phosphatase activity [GO:0004725];
SH3/SH2 adaptor activity [GO:0005070]
Gene Ontology
(Cellular Component)
Complete annatation
cytoplasm [GO:0005737];
cytosol [GO:0005829];
mitochondrion [GO:0005739];
nucleus [GO:0005634];
protein complex [GO:0043234]
Protein-protein interaction111745
Phylogenetic treeQ06124
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.028015272888310.001852475955294470.00620731827438824
AZA vs. DISU0.09109226701073550.7184644700847210.973374730783303
AZA vs. IL70.3205585251654960.09515246741319090.824387308020595
AZA vs. SAHA0.1463660619294430.5483997771747830.84617981140308
DISU vs. CD3-0.9499040015173530.009255245978742610.0271428724278673
DISU vs. IL70.2209294414112950.3798490993855850.750586600240883
DISU vs. SAHA0.05612654271103360.8475131728454210.959699799550203
DMSO vs. AZA-0.07195890241216220.6669267358180321
DMSO vs. CD3-1.111726120437740.0005788600285885350.00212356405053064
DMSO vs. DISU-0.1650811136955910.49829318532580.907526896115356
DMSO vs. IL70.3998955745404410.02610054911233990.329260065161945
DMSO vs. SAHA0.2110674747050280.3706236940465050.718168488360569
HIV vs. Mock in Activation0.1010768514389110.871629930302210.999983755607037
HIV vs. Mock in Latency-0.04736040348300050.7739343090667720.999834320637052
IL7 vs. CD3-0.6986490471453810.03010727995437360.0729207194748802
SAHA vs. CD3-0.9069345997152110.01089898949703060.0276325322544164
SAHA vs. IL7-0.1781675327456060.4649377797069090.700356959258714
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
-0.4205 0.02159

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.0122856 0.955098
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
0.994 0.951 0.967 1.039 0.984
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
unknown unknown unknown unknown unknown unknown unknown
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB02779 Dodecane-Trimethylamine experimental unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
2SHP X-ray 2.0Å A/B=1-529.
3B7O X-ray 1.6Å A=237-533.
3MOW X-ray 2.3Å A=262-532.
3O5X X-ray 2.0Å A=262-532.
3TKZ X-ray 1.8Å A=1-106.
3TL0 X-ray 2.0Å A=1-106.
3ZM0 X-ray 1.5Å A=248-531.
3ZM1 X-ray 1.4Å A=248-531.
3ZM2 X-ray 1.5Å A=248-531.
3ZM3 X-ray 1.5Å A=248-531.
4DGP X-ray 2.3Å A=1-532.
4DGX X-ray 2.3Å A=1-532.
4GWF X-ray 2.1Å A/B=1-543.
4H1O X-ray 2.2Å A=1-543.
4H34 X-ray 2.7Å A=1-543.
4JE4 X-ray 2.3Å A=1-103.
4JEG X-ray 2.3Å A=97-217.
4JMG X-ray 1.4Å B=579-591.
4NWF X-ray 2.1Å A/B=1-543.
4NWG X-ray 2.4Å A/B=1-543.
4OHD X-ray 2.7Å A=1-532.
4OHE X-ray 2.5Å A=1-467# A=469-532.
4OHH X-ray 2.7Å A=1-532.
4OHI X-ray 2.2Å A=1-532.
4OHL X-ray 2.4Å A/B=1-532.
4PVG X-ray 2.4Å A=240-532.
4QSY X-ray 2.1Å A=1-106.
4RDD X-ray 1.6Å A=262-532.
5DF6 X-ray 1.7Å A=1-222.
5EHP X-ray 1.8Å A/B=1-529.
5EHR X-ray 1.7Å A/B=1-529.
5I6V X-ray 1.8Å A/B=1-529.
5IBM X-ray 2.1Å A/B=1-529.
5IBS X-ray 2.3Å A/B=1-529.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Tat downregulates 24965120
Envelope surface glycoprotein gp120 activates 12824191

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa04014 Ras signaling pathway - Homo sapiens (human)
hsa04072 Phospholipase D signaling pathway - Homo sapiens (human)
hsa04360 Axon guidance - Homo sapiens (human)
hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
hsa04650 Natural killer cell mediated cytotoxicity - Homo sapiens (human)
hsa04670 Leukocyte transendothelial migration - Homo sapiens (human)
hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
hsa04931 Insulin resistance - Homo sapiens (human)
hsa05120 Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
hsa05168 Herpes simplex infection - Homo sapiens (human)
hsa05205 Proteoglycans in cancer - Homo sapiens (human)
hsa05211 Renal cell carcinoma - Homo sapiens (human)
hsa05220 Chronic myeloid leukemia - Homo sapiens (human)