Detailed entry information

Protein Information (annotations from UniProt)

Database IDHIV0002371
UniProt IDQ15185
Primary gene name(s)PTGES3
Synonym gene name(s)P23, TEBP
Protein nameProstaglandin E synthase 3
Protein functionCytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2, PGH2 to prostaglandin E2, PGE2, PubMed:10922363. Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes, PubMed:11274138, PubMed:12077419. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway, PubMed:24711448. {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.
Subcellular locationCytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}.
ECO codeClick here for more information.
Amino acid sequence
FASTA format: Q15185
Gene Ontology
(Biological Process)
Complete annatation
chaperone cofactor-dependent protein refolding [GO:0070389];
cyclooxygenase pathway [GO:0019371];
prostaglandin biosynthetic process [GO:0001516];
regulation of cellular response to heat [GO:1900034];
signal transduction [GO:0007165];
telomere maintenance [GO:0000723]
Gene Ontology
(Molecular Function)
Complete annatation
prostaglandin-E synthase activity [GO:0050220];
telomerase activity [GO:0003720];
unfolded protein binding [GO:0051082]
Gene Ontology
(Cellular Component)
Complete annatation
chromosome, telomeric region [GO:0000781];
cytoplasm [GO:0005737];
cytosol [GO:0005829];
extracellular exosome [GO:0070062];
nucleoplasm [GO:0005654];
nucleus [GO:0005634];
telomerase holoenzyme complex [GO:0005697]
Protein-protein interaction115952
Phylogenetic treeQ15185
HIV replication factor status Zhou et al., Cell. Host. Microbe., 2008
Brass et al., Science, 2008
Smith et al., J. Immunol, 2010
gene status
Lu et al., J. Virol., 2011
      Folds changes 8h: unknown; Folds changes 16h: unknown; Tested: unknown;
Schoggins JW and Rice CM, Curr. Opin. Virol., 2011
      Targeted viruses: unknown
      Viral life cycle: unknown
      Mechanism related to antiviral activity: unknown
Anti-viral restriction factor Liu et al., Retrovirology, 2011
      unknown (Triplicates)

Gene Expression Profile       top

            Up-regulated;            Down-regulated

For brief introduction to each study, please go to the help page.

Gene expression during HIV latency

(1). Mohammadi et al., PLoS Pathog., 2014

Differentially expressed transcripts (Pairwise) during latency and subsequent viral reactivation using several agents - Primary CD4+ T-cell based model

DMSO: Dimethyl suloxyde (negative control) - 0.0033% final
SAHA: Vorinostat (Histone deacetylase inhibitor) - 0.5 μM
CD3: TCR Stimulation by IL-2+ antiCD3/anti-CD28 antibodies
IL7: Interleukin-7 based stimulation
DISU: Disulfiram (alcohol dehydrogenase inhibitor) - 0.5 μM
AZA: 5-azacytidine (AZA; DNA methylation inhibitor) - 1 μM
Experimental Condition Log2 Fold Change P value Adjusted P value
AZA vs. CD31.492881074959777.70590425624995e-064.88702191542222e-05
AZA vs. DISU0.2760509507621610.2744773022989080.846086444137247
AZA vs. IL70.251821349859850.1892887343703030.952979086856458
AZA vs. SAHA-0.0378032341907810.8767032118125930.972484494565502
DISU vs. CD3-1.22931384030080.0008095013025284370.00345286435605933
DISU vs. IL7-0.03315057880294280.8950670423890770.98053444331394
DISU vs. SAHA-0.3130766625518170.2823066905670620.664061828240392
DMSO vs. AZA-0.1158909628943770.4877612067022731
DMSO vs. CD3-1.619743242342997.34721902651003e-075.42577718795949e-06
DMSO vs. DISU-0.3937470181159120.1063794880647180.580924146982464
DMSO vs. IL70.3749621071920910.03676859454537960.393949227271924
DMSO vs. SAHA0.07088442451536970.7634158218498860.931825079317738
HIV vs. Mock in Activation-0.2931968391910650.6371676396564020.999983755607037
HIV vs. Mock in Latency-0.01989393408600080.9039082293934790.999834320637052
IL7 vs. CD3-1.23244943919140.0001512370081303560.00083593524882613
SAHA vs. CD3-1.555892710895351.63538910712413e-059.63837068610115e-05
SAHA vs. IL7-0.2932681026704460.2281284404139880.468630159553075
(2). Iglesias-Ussel et al., J. Virol., 2013

Up and Downregulated transcripts during Latency (Latently infected CD4+ T cells vs Uninfected)- Primary CD4+Tcell based model
Log2 Fold Change P Value
unknown unknown

Gene expression during HIV infection and replication

(1). Imbeault et al., PloS Pathog., 2012

Transcriptomic profiling of HIV-1 infected CD4+ T cells - Primary CD4+ T cells
Experiment type Log2 Fold Change P Value Adjusted P Value
Infected vs. Mock unknown unknown unknown
Infected vs. Bystander unknown unknown unknown
(2). Lefebvre et al., J. Virol., 2011

Transcriptome analysis of T-cell line (Sup T1)
Log2 Fold Change unknown
(3). Li et al., J. Immunol., 2013

Lymphatic tissue
Acute Fold Change Acute P Value Asymt Fold Change Asypt P Value AIDS Fold Change AIDS P Value
unknown unknown unknown unknown unknown unknown
(4). Chang et al., MBio., 2011

Transcriptome analysis of T-cell line (Sup T1)

Derived from Sherrill-Mix et al., BMC Retrovirol., 2015 cross validation
Up-regulated (True) FALSE
(5). Sherrill-Mix et al., BMC Retrovirol., 2015

Deep RNA-seq analysis of primary human T cell infected with low passage HIV isolate HIV89.6 - Primary CD4+ T cell based
Test Status Log2 Fold Change P Value
OK 0.362424 0.0234913
(6). Rotger et al., PLoS Pathog., 2010

Genome-wide mRNA expression of CD4+ T cells from HIV-infected patient
(Genes differentially expressed (at adjusted p<0.01) according to the empirical Bayes approach)
Log2 Fold Change P Value
unknown unknown

Proteomic/Transcriptomics studies indicating differentially expressed genes mediated by HIV

(1). Greenwood et al., Elife, 2016

Activated (CD3/CD28) Primary human CD4+ T cells infected with pNL4-3-dE-EGFP. The table shows the complete (unfiltered) TMT (tandem mass tag)-based proteomic time course dataset
6 h 24 h 48 h 72 h RTi
1.018 0.97 0.981 1.001 0.958
(2). Navare et al., Virology, 2012

SUP-T1 cell line
FC-4hpi P-value FC-8hpi P-value FC-20hpi P-value Category
0.5 0.0051 0.2 0.2367 -0.03 0.6089 Cell growth and proliferation at 4 hpi
(3). Hyrcza et al., J. Virolo., 2007

Primary human CD4+ and CD8+ T Cells
Affymetrix Prob ID Fold Change In CD8? Category
unknown unknown unknown unknown

Protein Overview       top

Drug-protein Interaction       (annotations from DrugBank)      top

Drugbank ID Drug Name Drug Status Pharmacological Action Drug Action
DB05036 Grn163l investigational unknown unknown

Protein Secondary Structure       (annotations from PDB)      top

PDB Accession Method Resolution Chain Structure Preview
1EJF X-ray 2.4Å A/B=1-125.
1LG0 Model - A=1-110.

HIV-1 Interaction       (annotations from NCBI HIV-1 Interaction Database)      top

HIV Partner Interaction Type PubMed
Vpu interacts with 22190034
Vpr interacts with 11531413
Rev interacts with 22174317
HIV-1 virus replication enhanced by expression of human gene 18854154

Metabolic/Signalling Pathway       (annotations from KEGG database)      top

Pathway Accession Number Description
hsa00590 Arachidonic acid metabolism - Homo sapiens (human)
hsa01100 Metabolic pathways - Homo sapiens (human)